4RWO
Crystal structure of the porcine OAS1 L149R mutant in complex with dsRNA and ApCpp in the AMP donor position
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3') | polymer | 19 | 6017.6 | 1 | SYNTHETIC CONSTRUCT | ||
2 | C | RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3') | polymer | 19 | 6069.7 | 1 | SYNTHETIC CONSTRUCT | ||
3 | A | 2'-5'-oligoadenylate synthase 1 | polymer | 357 | 41322.4 | 1 | UniProt (Q29599) Pfam (PF01909) Pfam (PF10421) In PDB | Sus scrofa (pigs swine wild boar) | (2-5')oligo(A) synthase 1, 2-5A synthase 1, p42 OAS |
4 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | A | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | non-polymer | 505.2 | 1 | Chemie (APC) | |||
6 | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A: 1 - 349 (UniProt: Q29599)
PDB | External Database | Details |
---|---|---|
Arg 149 | Leu 149 | engineered mutation |
Gly 350 | - | expression tag |
Ser 351 | - | expression tag |
His 352 | - | expression tag |
His 353 | - | expression tag |
His 354 | - | expression tag |
His 355 | - | expression tag |
His 356 | - | expression tag |
His 357 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 53409.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 553.8 | |
All* | Total formula weight | 53963.4 |