4RWP

Crystal structure of porcine OAS1 in complex with dsRNA

Summary for 4RWP

Related4RWN 4RWO 4RWQ
Descriptor2'-5'-oligoadenylate synthase 1, RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3'), RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3'), ... (4 entities in total)
Functional Keywordsinterferon-induced, dsrna-activated, transferase-rna complex, transferase/rna
Biological sourceSus scrofa (pigs,swine,wild boar)
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Cellular locationCytoplasm  Q29599
Total number of polymer chains3
Total molecular weight53365.59
Authors
Primary citation
Lohofener, J.,Steinke, N.,Kay-Fedorov, P.,Baruch, P.,Nikulin, A.,Tishchenko, S.,Manstein, D.J.,Fedorov, R.
The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity.
Structure, 23:851-862, 2015
PubMed: 25892109 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2015.03.012
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.25 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.22530.3%1.3%4.2%0.82MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution