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4RWN

Crystal structure of the pre-reactive state of porcine OAS1

Summary for 4RWN
Entry DOI10.2210/pdb4rwn/pdb
Related4RWO 4RWP 4RWQ
Descriptor2'-5'-oligoadenylate synthase 1, RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3'), RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3'), ... (6 entities in total)
Functional Keywordsinnate immunity, pathogen rna sensor, interferon-induced, dsrna-activated, transferase-rna complex, transferase/rna
Biological sourceSus scrofa (pigs,swine,wild boar)
More
Cellular locationCytoplasm : Q29599
Total number of polymer chains3
Total formula weight54473.22
Authors
Lohoefener, J.,Steinke, N.,Kay-Fedorov, P.,Baruch, P.,Nikulin, A.,Tishchenko, S.,Manstein, D.J.,Fedorov, R. (deposition date: 2014-12-05, release date: 2015-05-20, Last modification date: 2024-02-28)
Primary citationLohofener, J.,Steinke, N.,Kay-Fedorov, P.,Baruch, P.,Nikulin, A.,Tishchenko, S.,Manstein, D.J.,Fedorov, R.
The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity.
Structure, 23:851-862, 2015
Cited by
PubMed: 25892109
DOI: 10.1016/j.str.2015.03.012
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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