4RWN

Crystal structure of the pre-reactive state of porcine OAS1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001730	molecular_function	2'-5'-oligoadenylate synthetase activity
A	0002376	biological_process	immune system process
A	0003723	molecular_function	RNA binding
A	0003725	molecular_function	double-stranded RNA binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus
A	0060337	biological_process	type I interferon-mediated signaling pathway
A	0060700	biological_process	regulation of ribonuclease activity
A	0070106	biological_process	interleukin-27-mediated signaling pathway
A	0140374	biological_process	antiviral innate immune response
A	1904188	biological_process	negative regulation of transformation of host cell by virus

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE APC A 401

Chain	Residue
A	GLY61
A	TYR230
A	APC402
A	MG403
A	MG404
A	HOH501
A	HOH522
A	HOH541
A	HOH545
A	HOH563
A	HOH578
A	SER62
A	HOH593
A	HOH597
A	HOH623
A	HOH640
A	HOH658
A	LYS65
A	SER73
A	ASP74
A	ASP76
A	GLN193
A	LYS212
A	GLN229

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE APC A 402

Chain	Residue
A	ASP76
A	ARG129
A	ALA130
A	ASP147
A	LEU149
A	SER186
A	THR187
A	THR190
A	GLN193
A	APC401
A	MG404
A	HOH623
A	HOH678

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 403

Chain	Residue
A	ASP74
A	ASP76
A	APC401
A	MG404
A	HOH501

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 404

Chain	Residue
A	ASP74
A	ASP76
A	ASP147
A	APC401
A	APC402
A	MG403
A	HOH623

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 101

Chain	Residue
B	HOH217
B	HOH218
B	HOH219
B	HOH220
B	HOH236
B	HOH237

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 102

Chain	Residue
B	U16
B	HOH221
B	HOH222
B	HOH223
B	HOH238
B	HOH239

---

Functional Information from PROSITE/UniProt

site_id	PS00832
Number of Residues	20
Details	25A_SYNTH_1 2'-5'-oligoadenylate synthases signature 1. GSsGKgTtLRgrsDaDLVvF

Chain	Residue	Details
A	GLY61-PHE80

---

site_id	PS00833
Number of Residues	11
Details	25A_SYNTH_2 2'-5'-oligoadenylate synthases signature 2. RPVILDPaDPT

Chain	Residue	Details
A	ARG295-THR305

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	Region: {"description":"Interaction with dsRNA","evidences":[{"source":"UniProtKB","id":"P00973","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00973","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18604630","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14636576","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Interaction with dsRNA","evidences":[{"source":"UniProtKB","id":"P00973","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---