5NZJ

Crystal structure of UDP-glucose pyrophosphorylase G45Y mutant from Leishmania major in complex with UDP-glucose

Summary for 5NZJ

• Entry DOI: 10.2210/pdb5nzj/pdb
• Related: 2OEF 2OEG 4J18 4M28 4M2A 4M2B
• Descriptor: UDP-glucose pyrophosphorylase, URIDINE-5'-DIPHOSPHATE-GLUCOSE, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: ntp-transferase, pathogen, allostery, catalysis, transferase
• Biological source: Leishmania major
• Total number of polymer chains: 1
• Total formula weight: 57195.66

Authors

Cramer, J.T.,Fuehring, J.I.,Baruch, P.,Bruetting, C.,Hesse, R.,Knoelker, H.-J.,Gerardy-Schahn, R.,Fedorov, R. (deposition date: 2017-05-14, release date: 2018-04-18, Last modification date: 2024-11-06)

• Primary citation: Cramer, J.T.,Fuehring, J.I.,Baruch, P.,Bruetting, C.,Knoelker, H.-J.,Gerardy-Schahn, R.,Fedorov, R.; Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies; Acs Catalysis, 8:-, 2018; DOI: 10.1021/acscatal.7b03714

Experimental method

X-RAY DIFFRACTION (1.95 Å)