5NZJ

Crystal structure of UDP-glucose pyrophosphorylase G45Y mutant from Leishmania major in complex with UDP-glucose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005977	biological_process	glycogen metabolic process
A	0006011	biological_process	UDP-glucose metabolic process
A	0016779	molecular_function	nucleotidyltransferase activity
A	0031981	cellular_component	nuclear lumen
A	0070569	molecular_function	uridylyltransferase activity
A	0097014	cellular_component	ciliary plasm

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue UPG A 601

Chain	Residue
A	LEU81
A	LYS255
A	GLY256
A	GLY257
A	GLU284
A	PHE305
A	ASN306
A	ASN308
A	LYS380
A	HOH716
A	HOH741
A	GLY83
A	HOH762
A	HOH774
A	HOH790
A	HOH814
A	HOH837
A	GLY84
A	MET130
A	GLN162
A	GLY190
A	HIS191
A	ASN219
A	GLY220

---

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 602

Chain	Residue
A	THR381
A	CYS382
A	ALA383
A	LEU416
A	TYR421

---

site_id	AC3
Number of Residues	3
Details	binding site for residue EDO A 603

Chain	Residue
A	GLN74
A	GLN210
A	GLY211

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 604

Chain	Residue
A	GLN35
A	PRO189
A	ASP193
A	LEU352
A	HOH724

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 605

Chain	Residue
A	MET161
A	SER201
A	HOH727

---

site_id	AC6
Number of Residues	7
Details	binding site for residue EDO A 606

Chain	Residue
A	LYS167
A	TYR184
A	VAL339
A	ASP340
A	SER341
A	HOH706
A	HOH726

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO A 607

Chain	Residue
A	ARG118
A	ARG126
A	PHE127
A	GLU157
A	VAL158

---

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 A 608

Chain	Residue
A	ALA377
A	PRO378
A	ASP384
A	TYR393
A	HOH766

---