2XEL

Molecular Mechanism of Pentachloropseudilin Mediated Inhibition of Myosin Motor Activity

Summary for 2XEL

• Entry DOI: 10.2210/pdb2xel/pdb
• Related: 1D0X 1D0Y 1D0Z 1D1A 1D1B 1D1C 1FMV 1FMW 1G8X 1JWY 1JX2 1LVK 1MMA 1MMD 1MMG 1MMN 1MND 1MNE 1Q5G 1VOM 1W9I 1W9J 1W9K 1W9L 1YV3 2AKA 2JHR 2JJ9 2X9H
• Descriptor: MYOSIN-2 HEAVY CHAIN, ADP METAVANADATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: contractile protein, allosteric inhibitor, non-hydroylsable atp analogue, motor protein
• Biological source: DICTYOSTELIUM DISCOIDEUM (SLIME MOLD)
• Cellular location: Cytoplasm, cell cortex: P08799
• Total number of polymer chains: 1
• Total formula weight: 89396.83

Authors

Chinthalapudi, K.,Taft, M.H.,Martin, R.,Hartmann, F.K.,Heissler, S.M.,Tsiavaliaris, G.,Gutzeit, H.O.,Knoelker, H.J.,Coluccio, L.M.,Fedorov, R.,Manstein, D.J. (deposition date: 2010-05-16, release date: 2011-06-15, Last modification date: 2011-08-31)

• Primary citation: Chinthalapudi, K.,Taft, M.H.,Martin, R.,Heissler, S.M.,Preller, M.,Hartmann, F.K.,Brandstaetter, H.,Kendrick-Jones, J.,Tsiavaliaris, G.,Gutzeit, H.O.,Fedorov, R.,Buss, F.,Knoelker, H.J.,Coluccio, L.M.,Manstein, D.J.; Mechanism and Specificity of Pentachloropseudilin-Mediated Inhibition of Myosin Motor Activity.; J.Biol.Chem., 286:29700-, 2011; PubMed: 21680745; DOI: 10.1074/JBC.M111.239210

Experimental method

X-RAY DIFFRACTION (2.5 Å)