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1QAW
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BU of 1qaw by Molmil
Regulatory Features of the TRP Operon and the Crystal Structure of the TRP RNA-Binding Attenuation Protein from Bacillus Stearothermophilus.
分子名称: TRP RNA-BINDING ATTENUATION PROTEIN, TRYPTOPHAN
著者Chen, X.-P, Antson, A.A, Yang, M, Baumann, C, Dodson, E.J, Dodson, G.G, Gollnick, P.
登録日1999-03-31
公開日1999-04-16
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Regulatory features of the trp operon and the crystal structure of the trp RNA-binding attenuation protein from Bacillus stearothermophilus.
J.Mol.Biol., 289, 1999
6VBK
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BU of 6vbk by Molmil
Crystal structure of N-terminal domain of Mycobacterium tuberculosis complex Lon protease
分子名称: GLYCEROL, Lon211
著者Bi, F.K, Chen, C, Chen, X.Y, Guo, C.Y, Lin, D.H.
登録日2019-12-19
公開日2020-12-23
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the N domain of Lon protease from Mycobacterium avium complex.
Protein Sci., 28, 2019
4DT6
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BU of 4dt6 by Molmil
Co-crystal structure of eIF4E with inhibitor
分子名称: 1,2-ETHANEDIOL, 7-[2-(4-chlorophenoxy)ethyl]guanosine 5'-(dihydrogen phosphate), Eukaryotic translation initiation factor 4E, ...
著者Min, X, Johnstone, S, Walker, N, Wang, Z.
登録日2012-02-20
公開日2012-04-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction.
J.Med.Chem., 55, 2012
4DUM
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BU of 4dum by Molmil
Co-crystal structure of eIF4E with inhibitor
分子名称: (4-{7-[2-(4-chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl}phenyl)phosphonic acid, 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 4E
著者Min, X, Johnstone, S, Walker, N, Wang, Z.
登録日2012-02-22
公開日2012-04-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction.
J.Med.Chem., 55, 2012
4RXZ
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BU of 4rxz by Molmil
Crystal Structure of MDMX phosporylated Tyr99 in complex with a 12-mer peptide
分子名称: 12-MER PEPTIDE INHIBITOR, Protein Mdm4
著者Pazgier, M, Gohain, N, Tolbert, W.D.
登録日2014-12-12
公開日2015-07-22
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structural basis of how stress-induced MDMX phosphorylation activates p53.
Oncogene, 35, 2016
6KSE
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BU of 6kse by Molmil
Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria tuberculosisin complex with C18CoA
分子名称: Acyl-CoA dehydrogenase FadE5, FLAVIN-ADENINE DINUCLEOTIDE, STEAROYL-COENZYME A
著者Liu, X, Chen, X.B.
登録日2019-08-23
公開日2020-07-01
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.998 Å)
主引用文献Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.
Proc.Natl.Acad.Sci.USA, 117, 2020
6KPT
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BU of 6kpt by Molmil
Crystal Structure of Acyl-CoA Dehydrogenase FadE5 from Mycobacteria smegmatis
分子名称: Acyl-CoA dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE
著者Liu, X, Chen, X.B.
登録日2019-08-16
公開日2020-07-01
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.963 Å)
主引用文献Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.
Proc.Natl.Acad.Sci.USA, 117, 2020
6KRI
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BU of 6kri by Molmil
Crystal Structure of Acyl-CoA Dehydrogenase FadE5 from Mycobacteria smegmatis with product released
分子名称: Acyl-CoA dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION
著者Liu, X, Chen, X.B.
登録日2019-08-21
公開日2020-07-01
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.604 Å)
主引用文献Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.
Proc.Natl.Acad.Sci.USA, 117, 2020
6AIC
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BU of 6aic by Molmil
Crystal structures of the N-terminal domain of Staphylococcus aureus DEAD-box Cold shock RNA helicase CshA in complex with AMP
分子名称: ADENOSINE MONOPHOSPHATE, DEAD-box ATP-dependent RNA helicase CshA
著者Tian, T, Chengliang, W, Xiaobao, C, Xuan, Z, Jianye, Z.
登録日2018-08-22
公開日2018-11-21
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of the N-terminal domain of the Staphylococcus aureus DEAD-box RNA helicase CshA and its complex with AMP
Acta Crystallogr F Struct Biol Commun, 74, 2018
8JZU
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BU of 8jzu by Molmil
SLC15A4_TASL complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, TLR adapter,Green fluorescent protein, TSLAA-EGPF tag fusion protein
著者Zhang, S.S, Chen, X.D, Xie, M.
登録日2023-07-06
公開日2023-09-27
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling.
Nat Commun, 14, 2023
8JZS
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BU of 8jzs by Molmil
Outward-facing SLC15A4 dimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, lysosomal transporter
著者Zhang, S.S, Chen, X.D, Xie, M.
登録日2023-07-06
公開日2023-09-27
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling.
Nat Commun, 14, 2023
8JZR
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BU of 8jzr by Molmil
Outward_facing SLC15A4 monomer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, lysosomal transporter,ALFA tag
著者Zhang, S.S, Chen, X.D, Xie, M.
登録日2023-07-06
公開日2023-09-27
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling.
Nat Commun, 14, 2023
7FJQ
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BU of 7fjq by Molmil
Cryo EM structure of lysosomal ATPase
分子名称: Polyamine-transporting ATPase 13A2, SPERMINE
著者Zhang, S.S.
登録日2021-08-04
公開日2023-03-08
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Cryo-EM structures and transport mechanism of human P5B type ATPase ATP13A2.
Cell Discov, 7, 2021
7FJP
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BU of 7fjp by Molmil
Cryo EM structure of lysosomal ATPase
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
著者Zhang, S.S.
登録日2021-08-04
公開日2023-03-08
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Cryo-EM structures and transport mechanism of human P5B type ATPase ATP13A2.
Cell Discov, 7, 2021
5XSU
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BU of 5xsu by Molmil
novel orally efficacious inhibitors complexed with PARP1
分子名称: 6-fluoranyl-2-(4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-yl)-1~{H}-benzimidazole-4-carboxamide, Poly [ADP-ribose] polymerase 1, SULFATE ION
著者Liu, Q, Xu, Y.
登録日2017-06-15
公開日2018-04-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors
Eur J Med Chem, 145, 2018
5XST
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BU of 5xst by Molmil
novel orally efficacious inhibitors complexed with PARP1
分子名称: 6-fluoranyl-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-1~{H}-benzimidazole-4-carboxamide, Poly [ADP-ribose] polymerase 1, SULFATE ION
著者Liu, Q, Xu, Y.
登録日2017-06-15
公開日2018-04-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors
Eur J Med Chem, 145, 2018
5XSR
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BU of 5xsr by Molmil
novel orally efficacious inhibitors complexed with PARP1
分子名称: 6-fluoranyl-2-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-1~{H}-benzimidazole-4-carboxamide, Poly [ADP-ribose] polymerase 1, SULFATE ION
著者Liu, Q, Xu, Y.
登録日2017-06-15
公開日2018-04-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors
Eur J Med Chem, 145, 2018
1CN3
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BU of 1cn3 by Molmil
INTERACTION OF POLYOMAVIRUS INTERNAL PROTEIN VP2 WITH MAJOR CAPSID PROTEIN VP1 AND IMPLICATIONS FOR PARTICIPATION OF VP2 IN VIRAL ENTRY
分子名称: COAT PROTEIN VP1, FRAGMENT OF COAT PROTEIN VP2
著者Chen, X, Stehle, T, Harrison, S.C.
登録日1999-05-24
公開日1999-06-09
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Interaction of polyomavirus internal protein VP2 with the major capsid protein VP1 and implications for participation of VP2 in viral entry.
EMBO J., 17, 1998
4O33
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BU of 4o33 by Molmil
Crystal Structure of human PGK1 3PG and terazosin(TZN) ternary complex
分子名称: 3-PHOSPHOGLYCERIC ACID, Phosphoglycerate kinase 1, [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl][(2R)-tetrahydrofuran-2-yl]methanone
著者Li, X.L, Finci, L.I, Wang, J.H.
登録日2013-12-18
公開日2014-10-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Terazosin activates Pgk1 and Hsp90 to promote stress resistance.
Nat.Chem.Biol., 11, 2015
4O3F
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BU of 4o3f by Molmil
Crystal Structure of mouse PGK1 3PG and terazosin(TZN) ternary complex
分子名称: 3-PHOSPHOGLYCERIC ACID, Phosphoglycerate kinase 1, [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl][(2R)-tetrahydrofuran-2-yl]methanone
著者Li, X.L, Finci, I.L, Wang, J.H.
登録日2013-12-18
公開日2014-10-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.106 Å)
主引用文献Terazosin activates Pgk1 and Hsp90 to promote stress resistance.
Nat.Chem.Biol., 11, 2015
3DR9
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BU of 3dr9 by Molmil
Increased Distal Histidine Conformational Flexibility in the Deoxy Form of Dehaloperoxidase from Amphitrite ornata
分子名称: Dehaloperoxidase A, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
著者Chen, X, de Serrano, V.S, Betts, L, Franzen, S.
登録日2008-07-10
公開日2009-01-27
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献Distal histidine conformational flexibility in dehaloperoxidase from Amphitrite ornata.
Acta Crystallogr.,Sect.D, 65, 2009
7F6V
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BU of 7f6v by Molmil
Cryo-EM structure of the human TACAN channel in a closed state
分子名称: CHOLESTEROL, Ion channel TACAN
著者Chen, X.Z, Wang, Y.J, Li, Y, Yang, X, Shen, Y.Q.
登録日2021-06-25
公開日2022-02-16
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.66 Å)
主引用文献Cryo-EM structure of the human TACAN in a closed state.
Cell Rep, 38, 2022
6UBF
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BU of 6ubf by Molmil
Role of Beta-hairpin motifs in the DNA duplex opening by the Rad4/XPC nucleotide excision repair complex
分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*AP*GP*CP*GP*GP*GP*AP*TP*GP*TP*CP*GP*AP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*TP*GP*AP*CP*TP*CP*(G47)P*AP*CP*AP*TP*CP*CP*C*GP*CP*TP*AP*CP*AP*A)-3'), DNA repair protein RAD4, ...
著者Paul, D, Min, J.H.
登録日2019-09-11
公開日2020-10-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (4.597 Å)
主引用文献Kinetic gating mechanism of DNA damage recognition by Rad4/XPC.
Nat Commun, 6, 2015
6J67
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BU of 6j67 by Molmil
Crystal structure of the compound 34 in a complex with TRF2
分子名称: 3FB-PHE-B8R-LEU-5XU-PRO, Telomeric repeat-binding factor 2
著者Chen, Y, Yang, Y, Lei, M.
登録日2019-01-14
公開日2019-02-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction.
ACS Med Chem Lett, 9, 2018
6AIB
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Crystal structures of the N-terminal RecA-like domain 1 of Staphylococcus aureus DEAD-box Cold shock RNA helicase CshA
分子名称: DEAD-box ATP-dependent RNA helicase CshA
著者Chengliang, W, Tian, T, Xiaobao, C, Xuan, Z, Jianye, Z.
登録日2018-08-22
公開日2018-11-21
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structures of the N-terminal domain of the Staphylococcus aureus DEAD-box RNA helicase CshA and its complex with AMP
Acta Crystallogr F Struct Biol Commun, 74, 2018

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