6LS4

A novel anti-tumor agent S-40 in complex with tubulin

Summary for 6LS4

Entry DOI	10.2210/pdb6ls4/pdb
Descriptor	Tubulin alpha-1B chain, Tubulin beta chain, Stathmin, ... (10 entities in total)
Functional Keywords	mitosis, antitumor protein, structural protein
Biological source	Sus scrofa (Pig) More
Total number of polymer chains	5
Total formula weight	221758.00
Authors	Du, T.,Lin, S.,Ji, M.,Xue, N.,Liu, Y.,Zhang, K.,Lu, D.,Chen, X.,Xu, H. (deposition date: 2020-01-17, release date: 2021-01-20, Last modification date: 2023-11-29)
Primary citation	Du, T.,Lin, S.,Ji, M.,Xue, N.,Liu, Y.,Zhang, Z.,Zhang, K.,Zhang, J.,Zhang, Y.,Wang, Q.,Sheng, L.,Li, Y.,Lu, D.,Chen, X.,Xu, H. A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity. Cancer Lett., 495:22-32, 2020 Cited by PubMed: 32931884 DOI: 10.1016/j.canlet.2020.08.040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation