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8RI9
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BU of 8ri9 by Molmil
Late alpha-Synuclein fibril structure from liquid-liquid phase separations.
分子名称: Alpha-synuclein
著者De Simone, A, Barritt, J.D, Chen, S, Cascella, R, Cecchi, C, Bigi, A, Jarvis, J.A, Chiti, F, Dobson, C.M, Fusco, G.
登録日2023-12-18
公開日2024-03-06
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure-Toxicity Relationship in Intermediate Fibrils from alpha-Synuclein Condensates.
J.Am.Chem.Soc., 146, 2024
2PX1
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BU of 2px1 by Molmil
crystal structure of the complex of bovine lactoferrin C-lobe with Ribose at 2.5 A resolution
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, FE (III) ION, ...
著者Mir, R, Vikram, G, Sinha, M, Sharma, S, Kaur, P, Singh, T.P.
登録日2007-05-14
公開日2007-05-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献crystal structure of the complex of bovine lactoferrin C-lobe with Ribose at 2.5 A resolution
To be Published
2XUE
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BU of 2xue by Molmil
CRYSTAL STRUCTURE OF JMJD3
分子名称: 2-OXOGLUTARIC ACID, FE (III) ION, LYSINE-SPECIFIC DEMETHYLASE 6B, ...
著者Chung, C, Rowland, P, Mosley, J, Thomas, P.J.
登録日2010-10-19
公開日2011-12-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Selective Jumonji H3K27 Demethylase Inhibitor Modulates the Proinflammatory Macrophage Response
Nature, 488, 2012
4CFK
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BU of 4cfk by Molmil
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH LY294002
分子名称: 1,2-ETHANEDIOL, 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE, BRD4 PROTEIN, ...
著者Chung, C, Dittmann, A, Drewes, G.
登録日2013-11-18
公開日2014-01-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献The Commonly Used Pi3-Kinase Probe Ly294002 is an Inhibitor of Bet Bromodomains.
Acs Chem.Biol., 9, 2014
4CFL
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BU of 4cfl by Molmil
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH LY303511
分子名称: 1,2-ETHANEDIOL, 8-phenyl-2-piperazin-1-yl-chromen-4-one, BRD4 PROTEIN, ...
著者Chung, C, Dittmann, A, Drewes, G.
登録日2013-11-18
公開日2014-01-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献The Commonly Used Pi3-Kinase Probe Ly294002 is an Inhibitor of Bet Bromodomains.
Acs Chem.Biol., 9, 2014
1JQ9
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BU of 1jq9 by Molmil
Crystal structure of a complex formed between phospholipase A2 from Daboia russelli pulchella and a designed pentapeptide Phe-Leu-Ser-Tyr-Lys at 1.8 resolution
分子名称: ACETIC ACID, Peptide inhibitor, Phospholipase A2
著者Chandra, V, Jasti, J, Kaur, P, Dey, S, Betzel, C, Singh, T.P.
登録日2001-08-04
公開日2002-11-06
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure of a Complex Formed between a Snake Venom Phospholipase A2 and a Potent Peptide Inhibitor Phe-Leu-Ser-Tyr-Lys at 1.8 A Resolution
J.BIOL.CHEM., 277, 2002
6SAR
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BU of 6sar by Molmil
E coli BepA/YfgC
分子名称: Beta-barrel assembly-enhancing protease, SULFATE ION, ZINC ION
著者Lovering, A.L, Cadby, I.T.
登録日2019-07-17
公開日2020-08-26
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Structure-Function Characterization of the Conserved Regulatory Mechanism of the Escherichia coli M48 Metalloprotease BepA.
J.Bacteriol., 203, 2020
2MPG
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BU of 2mpg by Molmil
Solution structure of the [AibB8,LysB28,ProB29]-insulin analogue
分子名称: Insulin A chain, Insulin B chain
著者Kosinova, L, Jiracek, J, Zakova, L, Veverka, V.
登録日2014-05-17
公開日2014-06-11
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin.
Biochemistry, 53, 2014
1L3P
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BU of 1l3p by Molmil
CRYSTAL STRUCTURE OF THE FUNCTIONAL DOMAIN OF THE MAJOR GRASS POLLEN ALLERGEN Phl p 5b
分子名称: MAGNESIUM ION, PHOSPHATE ION, POLLEN ALLERGEN Phl p 5b
著者Rajashankar, K.R, Bufe, A, Weber, W, Eschenburg, S, Lindner, B, Betzel, C.
登録日2002-02-28
公開日2003-02-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structure of the functional domain of the major grass-pollen allergen Phlp 5b.
Acta Crystallogr.,Sect.D, 58, 2002
7P6Y
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BU of 7p6y by Molmil
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH compound 5ef
分子名称: 4-benzoyl-N-(2-(2-(2-((2-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-6-yl)(methyl)amino)ethoxy)ethoxy)ethyl)-N-(2-oxo-2-((2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)amino)ethyl)benzamide, Bromodomain-containing protein 4
著者Chung, C.
登録日2021-07-18
公開日2021-10-06
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.881 Å)
主引用文献One-Step Synthesis of Photoaffinity Probes for Live-Cell MS-Based Proteomics.
Chemistry, 27, 2021
7P6V
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BU of 7p6v by Molmil
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH compound 3ag
分子名称: Bromodomain-containing protein 4, ethyl 2-(2-(4-azido-N-((2-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-6-yl)methyl)-2,3,5,6-tetrafluorobenzamido)acetamido)acetate
著者Chung, C.
登録日2021-07-18
公開日2021-10-06
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.17 Å)
主引用文献One-Step Synthesis of Photoaffinity Probes for Live-Cell MS-Based Proteomics.
Chemistry, 27, 2021
7P6W
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BU of 7p6w by Molmil
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH compound 3bg
分子名称: Bromodomain-containing protein 4, ethyl 2-(2-(4-azido-N-((2-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-6-yl)methyl)benzamido)acetamido)acetate
著者Chung, C.
登録日2021-07-18
公開日2021-10-06
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献One-Step Synthesis of Photoaffinity Probes for Live-Cell MS-Based Proteomics.
Chemistry, 27, 2021
2PI6
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BU of 2pi6 by Molmil
Crystal structure of the sheep signalling glycoprotein (SPS-40) complex with 2-methyl-2-4-pentanediol at 1.65A resolution reveals specific binding characteristics of SPS-40
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Chitinase-3-like protein 1, ETHANOL, ...
著者Sharma, P, Singh, N, Sharma, S, Kaur, P, Betzel, C, Singh, T.P.
登録日2007-04-13
公開日2007-05-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Tryptophan as a three-way switch in regulating the function of the secretory signalling glycoprotein (SPS-40) from mammary glands: structure of SPS-40 complexed with 2-methylpentane-2,4-diol at 1.6 A resolution.
Acta Crystallogr.,Sect.D, 65, 2009
1IFM
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BU of 1ifm by Molmil
TWO FORMS OF PF1 INOVIRUS: X-RAY DIFFRACTION STUDIES ON A STRUCTURAL PHASE TRANSITION AND A CALCULATED LIBRATION NORMAL MODE OF THE ASYMMETRIC UNIT
分子名称: INOVIRUS
著者Marvin, D.A.
登録日1994-01-31
公開日1994-07-31
最終更新日2024-02-07
実験手法FIBER DIFFRACTION (3.3 Å)
主引用文献Two Forms of Pf1 Inovirus: X-Ray Diffraction Studies on a Structural Phase Transition and a Calculated Libration Normal Mode of the Asymmetric Unit
Phase Transitions, 39, 1992
7PJF
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BU of 7pjf by Molmil
Inhibiting parasite proliferation using a rationally designed anti-tubulin agent
分子名称: Designed ankyrin repeat protein (DARPIN) D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O.
登録日2021-08-24
公開日2021-09-22
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.862 Å)
主引用文献Inhibiting parasite proliferation using a rationally designed anti-tubulin agent.
Embo Mol Med, 13, 2021
7PJE
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BU of 7pje by Molmil
Inhibiting parasite proliferation using a rationally designed anti-tubulin agent
分子名称: Darpin D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O.
登録日2021-08-24
公開日2021-09-22
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Inhibiting parasite proliferation using a rationally designed anti-tubulin agent.
Embo Mol Med, 13, 2021
5V6M
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BU of 5v6m by Molmil
Crystal Structure of Rabbit Anti-HIV-1 gp120 V3 Fab 10A3 in complex with V3 peptide ConB
分子名称: CALCIUM ION, Envelope glycoprotein gp120 V3 peptide of Con B sequence, Heavy chain of Fab fragment of rabbit anti-HIV1 gp120 V3 mAb 10A3, ...
著者Pan, R, Kong, X.-P.
登録日2017-03-17
公開日2018-01-17
最終更新日2019-12-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Increased epitope complexity correlated with antibody affinity maturation and a novel binding mode revealed by structures of rabbit antibodies against the third variable loop (V3) of HIV-1 gp120.
J. Virol., 2018
5V6L
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BU of 5v6l by Molmil
Crystal Structure of Rabbit Anti-HIV-1 gp120 V3 Fab 10A37 in complex with V3 peptide JR-FL
分子名称: Envelope glycoprotein, v3 region, Heavy chain of Fab fragment of rabbit anti-HIV1 gp120 V3 mAb 10A37, ...
著者Pan, R, Kong, X.-P.
登録日2017-03-17
公開日2018-01-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.549 Å)
主引用文献Increased epitope complexity correlated with antibody affinity maturation and a novel binding mode revealed by structures of rabbit antibodies against the third variable loop (V3) of HIV-1 gp120.
J. Virol., 2018
1LDG
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BU of 1ldg by Molmil
PLASMODIUM FALCIPARUM L-LACTATE DEHYDROGENASE COMPLEXED WITH NADH AND OXAMATE
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-LACTATE DEHYDROGENASE, OXAMIC ACID
著者Dunn, C, Banfield, M, Barker, J, Higham, C, Moreton, K, Turgut-Balik, D, Brady, L, Holbrook, J.J.
登録日1996-09-10
公開日1997-09-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design.
Nat.Struct.Biol., 3, 1996
7Q3U
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BU of 7q3u by Molmil
Cryo-EM structure of TDP43 core peptide amyloid fiber
分子名称: TAR DNA-binding protein 43
著者Nazarov, S.
登録日2021-10-28
公開日2023-03-22
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage.
Nat.Neurosci., 26, 2023
4ASK
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BU of 4ask by Molmil
CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1
分子名称: 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, COBALT (II) ION, LYSINE-SPECIFIC DEMETHYLASE 6B, ...
著者Chung, C, Mosley, J, Liddle, J.
登録日2012-05-01
公開日2012-07-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献A Selective Jumonji H3K27 Demethylase Inhibitor Modulates the Proinflammatory Macrophage Response
Nature, 488, 2012
4F8C
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BU of 4f8c by Molmil
Structure of the Cif:Nedd8 complex - Yersinia pseudotuberculosis Cycle Inhibiting Factor in complex with human Nedd8
分子名称: 1,2-ETHANEDIOL, Cycle Inhibiting Factor, NEDD8
著者Crow, A, Banfield, M.
登録日2012-05-17
公開日2012-06-20
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The molecular basis of Nedd8 deamidation by the bacterial effector protein Cif
Proc.Natl.Acad.Sci.USA, 2012
6HAR
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BU of 6har by Molmil
Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C
分子名称: 1,2-ETHANEDIOL, Amyloid-beta A4 protein, CALCIUM ION, ...
著者Shahar, A, Cohen, I, Radisky, E, Papo, N.
登録日2018-08-08
公開日2019-02-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.497 Å)
主引用文献Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.
J.Biol.Chem., 294, 2019
4XTQ
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BU of 4xtq by Molmil
Crystal structure of a mutant (C20S) of a near-infrared fluorescent protein BphP1-FP
分子名称: 3-[2-[(Z)-[5-[(Z)-[(3R,4R)-3-ethenyl-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-pyrrol-2-ylidene]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, BphP1-FP/C20S, CHLORIDE ION
著者Pletnev, S, Malashkevich, V.N.
登録日2015-01-23
公開日2015-12-09
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Molecular Basis of Spectral Diversity in Near-Infrared Phytochrome-Based Fluorescent Proteins.
Chem.Biol., 22, 2015
4Q92
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BU of 4q92 by Molmil
1.90 Angstrom resolution crystal structure of apo betaine aldehyde dehydrogenase (betB) G234S mutant from Staphylococcus aureus (IDP00699) with BME-modified Cys289
分子名称: Betaine aldehyde dehydrogenase, DI(HYDROXYETHYL)ETHER, SODIUM ION
著者Halavaty, A.S, Minasov, G, Chen, C, Joo, J.C, Yakunin, A.F, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2014-04-28
公開日2014-05-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus.
Acta Crystallogr.,Sect.D, 71, 2015

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