7P6Y

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH compound 5ef

This is a non-PDB format compatible entry.

Summary for 7P6Y

• Entry DOI: 10.2210/pdb7p6y/pdb
• Related: 7P6V 7P6W
• Descriptor: Bromodomain-containing protein 4, 4-benzoyl-N-(2-(2-(2-((2-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-6-yl)(methyl)amino)ethoxy)ethoxy)ethyl)-N-(2-oxo-2-((2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)amino)ethyl)benzamide (3 entities in total)
• Functional Keywords: inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 31976.85

Authors

Chung, C. (deposition date: 2021-07-18, release date: 2021-10-06, Last modification date: 2021-12-29)

• Primary citation: Fallon, D.J.,Lehmann, S.,Chung, C.W.,Phillipou, A.,Eberl, C.,Fantom, K.G.M.,Zappacosta, F.,Patel, V.K.,Bantscheff, M.,Schofield, C.J.,Tomkinson, N.C.O.,Bush, J.T.; One-Step Synthesis of Photoaffinity Probes for Live-Cell MS-Based Proteomics.; Chemistry, 27:17880-17888, 2021; PubMed: 34328642; DOI: 10.1002/chem.202102036

Experimental method

X-RAY DIFFRACTION (1.881 Å)