7P6V

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH compound 3ag

This is a non-PDB format compatible entry.

Summary for 7P6V

• Entry DOI: 10.2210/pdb7p6v/pdb
• Descriptor: Bromodomain-containing protein 4, ethyl 2-(2-(4-azido-N-((2-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-6-yl)methyl)-2,3,5,6-tetrafluorobenzamido)acetamido)acetate (3 entities in total)
• Functional Keywords: inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15827.06

Authors

Chung, C. (deposition date: 2021-07-18, release date: 2021-10-06, Last modification date: 2021-12-29)

• Primary citation: Fallon, D.J.,Lehmann, S.,Chung, C.W.,Phillipou, A.,Eberl, C.,Fantom, K.G.M.,Zappacosta, F.,Patel, V.K.,Bantscheff, M.,Schofield, C.J.,Tomkinson, N.C.O.,Bush, J.T.; One-Step Synthesis of Photoaffinity Probes for Live-Cell MS-Based Proteomics.; Chemistry, 27:17880-17888, 2021; PubMed: 34328642; DOI: 10.1002/chem.202102036

Experimental method

X-RAY DIFFRACTION (1.17 Å)