4ASK

CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1

Summary for 4ASK

• Entry DOI: 10.2210/pdb4ask/pdb
• Related: 2XUE 2XXZ
• Descriptor: LYSINE-SPECIFIC DEMETHYLASE 6B, ZINC ION, 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, ... (5 entities in total)
• Functional Keywords: oxidoreductase, kdm6b, gsk-j1, inhibitor, lysine specific histone demethylase
• Biological source: HOMO SAPIENS
• Cellular location: Nucleus (Probable): O15054
• Total number of polymer chains: 2
• Total formula weight: 117128.15

Authors

Chung, C.,Mosley, J.,Liddle, J. (deposition date: 2012-05-01, release date: 2012-07-25, Last modification date: 2023-12-20)

• Primary citation: Kruidenier, L.,Chung, C.,Cheng, Z.,Liddle, J.,Che, K.,Joberty, G.,Bantscheff, M.,Bountra, C.,Bridges, A.,Diallo, H.,Eberhard, D.,Hutchinson, S.,Jones, E.,Katso, R.,Leveridge, M.,Mander, P.K.,Mosley, J.,Ramirez-Molina, C.,Rowland, P.,Schofield, C.J.,Sheppard, R.J.,Smith, J.E.,Swales, C.,Tanner, R.,Thomas, P.,Tumber, A.,Drewes, G.,Oppermann, U.,Patel, D.J.,Lee, K.,Wilson, D.M.; A Selective Jumonji H3K27 Demethylase Inhibitor Modulates the Proinflammatory Macrophage Response; Nature, 488:404-, 2012; PubMed: 22842901; DOI: 10.1038/NATURE11262

Experimental method

X-RAY DIFFRACTION (1.86 Å)