4ASK

CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	LYSINE-SPECIFIC DEMETHYLASE 6B	polymer	510	58050.3	2	UniProt (O15054) Pfam (PF02373) Pfam (PF21322) Pfam (PF21326) In PDB	HOMO SAPIENS	JMJC DOMAIN-CONTAINING PROTEIN 3, JUMONJI DOMAIN-CONTAINING PROTEIN 3, LYSINE DEMETHYLASE 6B JMJD3
2	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	A, B	3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid	non-polymer		389.4	2	Chemie (K0I)
4	A, B	COBALT (II) ION	non-polymer		58.9	2	Chemie (CO)
5		water	water		18.0	1239	Chemie (HOH)

Sequence modifications

A, B: 1141 - 1643 (UniProt: O15054)

PDB	External Database	Details
Met 1140	-	expression tag
His 1644	-	expression tag
His 1645	-	expression tag
His 1646	-	expression tag
His 1647	-	expression tag
His 1648	-	expression tag
His 1649	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	116100.6
Non-Polymers*	Number of molecules	6
	Total formula weight	1027.6
All*	Total formula weight	117128.2

*Water molecules are not included.