5V6M

Crystal Structure of Rabbit Anti-HIV-1 gp120 V3 Fab 10A3 in complex with V3 peptide ConB

Summary for 5V6M

• Entry DOI: 10.2210/pdb5v6m/pdb
• Related: 5V5L
• Descriptor: Light chain of Fab fragment of rabbit anti-HIV1 gp120 V3 mAb 10A3, Heavy chain of Fab fragment of rabbit anti-HIV1 gp120 V3 mAb 10A3, Envelope glycoprotein gp120 V3 peptide of Con B sequence, ... (5 entities in total)
• Functional Keywords: hiv, gp120, v3, antibody, viral protein-immune system complex, viral protein/immune system
• Biological source: Oryctolagus cuniculus (rabbit); More
• Total number of polymer chains: 3
• Total formula weight: 47401.87

Authors

Pan, R.,Kong, X.-P. (deposition date: 2017-03-17, release date: 2018-01-17, Last modification date: 2019-12-11)

• Primary citation: Pan, R.,Qin, Y.,Banasik, M.,Lees, W.,Shepherd, A.J.,Cho, M.W.,Kong, X.P.; Increased epitope complexity correlated with antibody affinity maturation and a novel binding mode revealed by structures of rabbit antibodies against the third variable loop (V3) of HIV-1 gp120.; J. Virol., 2018; PubMed: 29343576; DOI: 10.1128/JVI.01894-17

Experimental method

X-RAY DIFFRACTION (1.9 Å)