Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C

Summary for 6HAR

DescriptorPRSS3 protein, Amyloid-beta A4 protein, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordsprss3, mesotrypsin, serine protease, kunitz type inhibitor, appi, protein fibril
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight33430.5
Shahar, A.,Cohen, I.,Radisky, E.,Papo, N. (deposition date: 2018-08-08, release date: 2019-02-06, Last modification date: 2019-02-13)
Primary citation
Cohen, I.,Coban, M.,Shahar, A.,Sankaran, B.,Hockla, A.,Lacham, S.,Caulfield, T.R.,Radisky, E.S.,Papo, N.
Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.
J. Biol. Chem., 2019
PubMed: 30700553 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA118.007292
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.193200 1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6har
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Molmil generated image of 6har
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Molmil generated image of 6har
rotated about y axis by 90°
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