6HAR
Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | PRSS3 protein | polymer | 224 | 24257.5 | 1 | UniProt (Q8N2U3) Pfam (PF00089) In PDB | Homo sapiens (Human) | |
2 | E | Amyloid-beta A4 protein | polymer | 80 | 9070.9 | 1 | UniProt (H7C0V9) Pfam (PF00014) In PDB | Homo sapiens (Human) | |
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
4 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
5 | water | water | 18.0 | 250 | Chemie (HOH) |
Sequence modifications
A: 16 - 246 (UniProt: Q8N2U3)
E: 8 - 60 (UniProt: H7C0V9)
PDB | External Database | Details |
---|---|---|
Ala 195 | Ser 204 | conflict |
PDB | External Database | Details |
---|---|---|
Tyr -9 | - | expression tag |
Val -8 | - | expression tag |
Asp -7 | - | expression tag |
Tyr -6 | - | expression tag |
Lys -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Lys 0 | - | expression tag |
Glu 1 | - | expression tag |
Phe 2 | - | expression tag |
Glu 3 | - | expression tag |
Val 4 | - | expression tag |
Cys 5 | - | expression tag |
Ser 6 | - | expression tag |
Glu 7 | - | expression tag |
Cys 17 | Met 225 | engineered mutation |
Phe 18 | Ile 226 | engineered mutation |
Cys 34 | Phe 242 | engineered mutation |
Arg 61 | - | expression tag |
His 62 | - | expression tag |
His 63 | - | expression tag |
His 64 | - | expression tag |
His 65 | - | expression tag |
His 66 | - | expression tag |
His 67 | - | expression tag |
Ala 68 | - | expression tag |
Ala 69 | - | expression tag |
Ala 70 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 33328.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 102.1 | |
All* | Total formula weight | 33430.5 |