8RI9
Late alpha-Synuclein fibril structure from liquid-liquid phase separations.
Summary for 8RI9
| Entry DOI | 10.2210/pdb8ri9/pdb |
| EMDB information | 19184 |
| Descriptor | Alpha-synuclein (1 entity in total) |
| Functional Keywords | amyloid, fibril, neurodegeneration, parkinson's disease, protein fibril |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 5 |
| Total formula weight | 72380.54 |
| Authors | De Simone, A.,Barritt, J.D.,Chen, S.,Cascella, R.,Cecchi, C.,Bigi, A.,Jarvis, J.A.,Chiti, F.,Dobson, C.M.,Fusco, G. (deposition date: 2023-12-18, release date: 2024-03-06, Last modification date: 2024-05-01) |
| Primary citation | Chen, S.W.,Barritt, J.D.,Cascella, R.,Bigi, A.,Cecchi, C.,Banchelli, M.,Gallo, A.,Jarvis, J.A.,Chiti, F.,Dobson, C.M.,Fusco, G.,De Simone, A. Structure-Toxicity Relationship in Intermediate Fibrils from alpha-Synuclein Condensates. J.Am.Chem.Soc., 146:10537-10549, 2024 Cited by PubMed: 38567991DOI: 10.1021/jacs.3c14703 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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