4CFL

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH LY303511

Summary for 4CFL

Related4CFK
DescriptorBRD4 PROTEIN, 8-phenyl-2-piperazin-1-yl-chromen-4-one, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordscell cycle, inhibitor, histone, epigenetic reader, antagonist, kinase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight15559.9
Authors
Chung, C.,Dittmann, A.,Drewes, G. (deposition date: 2013-11-18, release date: 2014-01-15, Last modification date: 2014-03-05)
Primary citation
Dittmann, A.,Werner, T.,Chung, C.,Savitski, M.M.,Falth Savitski, M.,Grandi, P.,Hopf, C.,Lindon, M.,Neubauer, G.,Prinjha, R.K.,Bantscheff, M.,Drewes, G.
The Commonly Used Pi3-Kinase Probe Ly294002 is an Inhibitor of Bet Bromodomains.
Acs Chem.Biol., 9:495-, 2014
PubMed: 24533473 (PDB entries with the same primary citation)
DOI: 10.1021/CB400789E
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.32 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2233002.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4cfl
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Molmil generated image of 4cfl
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Molmil generated image of 4cfl
rotated about y axis by 90°