4CFK
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH LY294002
Summary for 4CFK
Entry DOI | 10.2210/pdb4cfk/pdb |
Related | 4CFL |
Descriptor | BRD4 PROTEIN, GLYCEROL, 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE, ... (5 entities in total) |
Functional Keywords | cell cycle, inhibitor, histone, epigenetic reader, antagonist |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 15560.88 |
Authors | Chung, C.,Dittmann, A.,Drewes, G. (deposition date: 2013-11-18, release date: 2014-01-15, Last modification date: 2024-05-08) |
Primary citation | Dittmann, A.,Werner, T.,Chung, C.,Savitski, M.M.,Falth Savitski, M.,Grandi, P.,Hopf, C.,Lindon, M.,Neubauer, G.,Prinjha, R.K.,Bantscheff, M.,Drewes, G. The Commonly Used Pi3-Kinase Probe Ly294002 is an Inhibitor of Bet Bromodomains. Acs Chem.Biol., 9:495-, 2014 Cited by PubMed: 24533473DOI: 10.1021/CB400789E PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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