7Q3U
Cryo-EM structure of TDP43 core peptide amyloid fiber
Summary for 7Q3U
| Entry DOI | 10.2210/pdb7q3u/pdb |
| EMDB information | 13795 |
| Descriptor | TAR DNA-binding protein 43 (1 entity in total) |
| Functional Keywords | tdp-43, amyloid, neurodegeneration, helical, cryo-em, rna binding protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 5 |
| Total formula weight | 40213.43 |
| Authors | Nazarov, S. (deposition date: 2021-10-28, release date: 2023-03-22, Last modification date: 2023-10-04) |
| Primary citation | Kumar, S.T.,Nazarov, S.,Porta, S.,Maharjan, N.,Cendrowska, U.,Kabani, M.,Finamore, F.,Xu, Y.,Lee, V.M.,Lashuel, H.A. Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage. Nat.Neurosci., 26:983-996, 2023 Cited by PubMed: 37248338DOI: 10.1038/s41593-023-01341-4 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.7 Å) |
Structure validation
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