5DLK
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![BU of 5dlk by Molmil](/molmil-images/mine/5dlk) | The crystal structure of CT mutant | Descriptor: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, TqaA | Authors: | Zhang, J.R, Tang, Y, Zhou, J.H. | Deposit date: | 2015-09-06 | Release date: | 2016-09-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis of nonribosomal peptide macrocyclization in fungi Nat.Chem.Biol., 12, 2016
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4FH7
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![BU of 4fh7 by Molmil](/molmil-images/mine/4fh7) | Structure of DHP A in complex with 2,4,6-tribromophenol in 20% methanol | Descriptor: | 2,4,6-TRIBROMOPHENOL, Dehaloperoxidase A, METHANOL, ... | Authors: | de Serrano, V.S, Franzen, S. | Deposit date: | 2012-06-05 | Release date: | 2013-03-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Structural and Kinetic Study of an Internal Substrate Binding Site in Dehaloperoxidase-Hemoglobin A from Amphitrite ornata. Biochemistry, 52, 2013
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4FH6
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![BU of 4fh6 by Molmil](/molmil-images/mine/4fh6) | Structure of DHP A in complex with 2,4,6-tribromophenol in 10% DMSO | Descriptor: | 2,4,6-TRIBROMOPHENOL, DIMETHYL SULFOXIDE, Dehaloperoxidase A, ... | Authors: | de Serrano, V.S, Franzen, S. | Deposit date: | 2012-06-05 | Release date: | 2013-03-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Structural and Kinetic Study of an Internal Substrate Binding Site in Dehaloperoxidase-Hemoglobin A from Amphitrite ornata. Biochemistry, 52, 2013
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8XG2
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![BU of 8xg2 by Molmil](/molmil-images/mine/8xg2) | The structure of HLA-A/Pep14 | Descriptor: | Beta-2-microglobulin, HLA class I heavy chain, Spike protein S1 | Authors: | Zhang, J.N, Yue, C, Liu, J. | Deposit date: | 2023-12-14 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Uncommon P1 Anchor-featured Viral T Cell Epitope Preference within HLA-A*2601 and HLA-A*0101 Individuals. Immunohorizons, 8, 2024
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7KGY
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![BU of 7kgy by Molmil](/molmil-images/mine/7kgy) | Beta-glucuronidase from Faecalibacterium prausnitzii bound to the inhibitor UNC10201652-glucuronide | Descriptor: | 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, Beta-glucuronidase, GLYCEROL | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2020-10-19 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun, 13, 2022
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7KGZ
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![BU of 7kgz by Molmil](/molmil-images/mine/7kgz) | |
4FBZ
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![BU of 4fbz by Molmil](/molmil-images/mine/4fbz) | Crystal structure of deltarhodopsin from Haloterrigena thermotolerans | Descriptor: | (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene, 2,3-DI-PHYTANYL-GLYCEROL, BACTERIORUBERIN, ... | Authors: | Kouyama, T. | Deposit date: | 2012-05-23 | Release date: | 2013-05-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of deltarhodopsin-3 from Haloterrigena thermotolerans Proteins, 81, 2013
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8HIP
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![BU of 8hip by Molmil](/molmil-images/mine/8hip) | dsRNA transporter | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Systemic RNA interference defective protein 1, ZINC ION, ... | Authors: | Jiang, D.H, Zhang, J.T. | Deposit date: | 2022-11-21 | Release date: | 2023-11-29 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Structural insights into double-stranded RNA recognition and transport by SID-1. Nat.Struct.Mol.Biol., 31, 2024
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8HKE
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![BU of 8hke by Molmil](/molmil-images/mine/8hke) | dsRNA transporter | Descriptor: | RNA (37-MER), Systemic RNA interference defective protein 1, ZINC ION | Authors: | Jiang, D.H, Zhang, J.T. | Deposit date: | 2022-11-25 | Release date: | 2023-11-29 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Structural insights into double-stranded RNA recognition and transport by SID-1. Nat.Struct.Mol.Biol., 31, 2024
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8J6O
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![BU of 8j6o by Molmil](/molmil-images/mine/8j6o) | transport T2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Green fluorescent protein (Fragment),SID1 transmembrane family member 2, ... | Authors: | Jiang, D.H, Zhang, J.T. | Deposit date: | 2023-04-26 | Release date: | 2024-05-01 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structural insights into double-stranded RNA recognition and transport by SID-1. Nat.Struct.Mol.Biol., 31, 2024
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8J6M
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![BU of 8j6m by Molmil](/molmil-images/mine/8j6m) | SIDT1 protein | Descriptor: | CHOLESTEROL, Green fluorescent protein,SID1 transmembrane family member 1, OLEIC ACID, ... | Authors: | Zhang, J.T, Jiang, D.H. | Deposit date: | 2023-04-26 | Release date: | 2024-05-01 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Structural insights into double-stranded RNA recognition and transport by SID-1. Nat.Struct.Mol.Biol., 31, 2024
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3RDH
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![BU of 3rdh by Molmil](/molmil-images/mine/3rdh) | X-ray induced covalent inhibition of 14-3-3 | Descriptor: | 14-3-3 protein zeta/delta, 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid, NICKEL (II) ION | Authors: | Horton, J.R, Upadhyay, A.K, Fu, H, Cheng, X. | Deposit date: | 2011-04-01 | Release date: | 2011-09-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proc.Natl.Acad.Sci.USA, 108, 2011
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4U5T
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![BU of 4u5t by Molmil](/molmil-images/mine/4u5t) | Crystal Structure of VBP Leucine Zipper with Bound Arylstibonic Acid | Descriptor: | (2Z)-3-{3-[dihydroxy(oxido)-lambda~5~-stibanyl]phenyl}prop-2-enoic acid, VBP leucine zipper | Authors: | Stagno, J.R, Ji, X. | Deposit date: | 2014-07-25 | Release date: | 2014-08-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.301 Å) | Cite: | P6981, an arylstibonic acid, is a novel low nanomolar inhibitor of cAMP response element-binding protein binding to DNA. Mol.Pharmacol., 82, 2012
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8GXL
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![BU of 8gxl by Molmil](/molmil-images/mine/8gxl) | HUMAN SUGP1 433-577 | Descriptor: | SURP and G-patch domain-containing protein 1 | Authors: | Xu, K, Tong, L. | Deposit date: | 2022-09-20 | Release date: | 2022-12-14 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer. Proc.Natl.Acad.Sci.USA, 119, 2022
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8GXM
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![BU of 8gxm by Molmil](/molmil-images/mine/8gxm) | HUMAN SUGP1 433-586 | Descriptor: | SURP and G-patch domain-containing protein 1 | Authors: | Xu, K, Tong, L. | Deposit date: | 2022-09-20 | Release date: | 2022-12-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer. Proc.Natl.Acad.Sci.USA, 119, 2022
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2XVO
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![BU of 2xvo by Molmil](/molmil-images/mine/2xvo) | SSO1725, a protein involved in the CRISPR/Cas pathway | Descriptor: | BETA-MERCAPTOETHANOL, SSO1725, SULFATE ION | Authors: | Reeks, J, Liu, H, Naismith, J, White, M, McMahon, S. | Deposit date: | 2010-10-26 | Release date: | 2010-12-29 | Last modified: | 2014-02-05 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Structure and Mechanism of the Cmr Complex for Crispr-Mediated Antiviral Immunity. Mol.Cell, 45, 2012
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6RX8
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![BU of 6rx8 by Molmil](/molmil-images/mine/6rx8) | |
6TYY
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![BU of 6tyy by Molmil](/molmil-images/mine/6tyy) | Hedgehog autoprocessing mutant D46H | Descriptor: | Protein hedgehog | Authors: | Li, H, Li, Z, Wang, C, Callahan, B.P. | Deposit date: | 2019-08-09 | Release date: | 2019-11-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing. J.Am.Chem.Soc., 141, 2019
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6RXA
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![BU of 6rxa by Molmil](/molmil-images/mine/6rxa) | EDDS lyase variant D290M/Y320M with bound formate | Descriptor: | Argininosuccinate lyase, FORMIC ACID, GLYCEROL, ... | Authors: | Grandi, E, Poelarends, G.J, Thunnissen, A.M.W.H. | Deposit date: | 2019-06-07 | Release date: | 2019-10-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Engineered C-N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners. Angew.Chem.Int.Ed.Engl., 59, 2020
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8FY5
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![BU of 8fy5 by Molmil](/molmil-images/mine/8fy5) | Human TMEM175-LAMP1 full-length complex | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | Authors: | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | Deposit date: | 2023-01-25 | Release date: | 2023-06-28 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83, 2023
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8FYF
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![BU of 8fyf by Molmil](/molmil-images/mine/8fyf) | Human TMEM175-LAMP1 transmembrane domain only complex | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | Authors: | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | Deposit date: | 2023-01-26 | Release date: | 2023-06-28 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83, 2023
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8E4A
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![BU of 8e4a by Molmil](/molmil-images/mine/8e4a) | Pseudomonas LpxC in complex with LPC-233 | Descriptor: | 4-(4-cyclopropylbuta-1,3-diyn-1-yl)-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION | Authors: | Najeeb, J, Zhou, P. | Deposit date: | 2022-08-17 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.034 Å) | Cite: | Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens. Sci Transl Med, 15, 2023
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8EJM
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![BU of 8ejm by Molmil](/molmil-images/mine/8ejm) | |
6EBU
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![BU of 6ebu by Molmil](/molmil-images/mine/6ebu) | Crystal structure of Aquifex aeolicus LpxE | Descriptor: | LpxE, SULFATE ION, octyl beta-D-glucopyranoside | Authors: | Wu, Q, Wang, S, Zhou, P. | Deposit date: | 2018-08-07 | Release date: | 2019-06-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.372 Å) | Cite: | The Lipid A 1-Phosphatase, LpxE, Functionally Connects Multiple Layers of Bacterial Envelope Biogenesis. Mbio, 10, 2019
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6GMI
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![BU of 6gmi by Molmil](/molmil-images/mine/6gmi) | Genetic Engineering of an Artificial Metalloenzyme for Transfer Hydrogenation of a Self-Immolative Substrate in E. coli's Periplasm. | Descriptor: | IRIDIUM (III) ION, Streptavidin, {N-(4-{[2-(amino-kappaN)ethyl]sulfamoyl-kappaN}phenyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide}(chloro)[(1,2,3,4,5-eta)-1,2,3,4,5-pentamethylcyclopentadienyl]iridium(III) | Authors: | Rebelein, J.G. | Deposit date: | 2018-05-26 | Release date: | 2018-10-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Genetic Engineering of an Artificial Metalloenzyme for Transfer Hydrogenation of a Self-Immolative Substrate in Escherichia coli's Periplasm. J. Am. Chem. Soc., 140, 2018
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