4U5T
Crystal Structure of VBP Leucine Zipper with Bound Arylstibonic Acid
Summary for 4U5T
Entry DOI | 10.2210/pdb4u5t/pdb |
Descriptor | VBP leucine zipper, (2Z)-3-{3-[dihydroxy(oxido)-lambda~5~-stibanyl]phenyl}prop-2-enoic acid (3 entities in total) |
Functional Keywords | leucine zipper, b-zip transcription factor, vitellogenin gene-binding protein (vbp), inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 9335.30 |
Authors | Stagno, J.R.,Ji, X. (deposition date: 2014-07-25, release date: 2014-08-06, Last modification date: 2023-08-30) |
Primary citation | Zhao, J.,Stagno, J.R.,Varticovski, L.,Nimako, E.,Rishi, V.,McKinnon, K.,Akee, R.,Shoemaker, R.H.,Ji, X.,Vinson, C. P6981, an arylstibonic acid, is a novel low nanomolar inhibitor of cAMP response element-binding protein binding to DNA. Mol.Pharmacol., 82:814-823, 2012 Cited by PubMed: 22851716DOI: 10.1124/mol.112.080820 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.301 Å) |
Structure validation
Download full validation report