4U5T

Crystal Structure of VBP Leucine Zipper with Bound Arylstibonic Acid

Summary for 4U5T

Entry DOI	10.2210/pdb4u5t/pdb
Descriptor	VBP leucine zipper, (2Z)-3-{3-[dihydroxy(oxido)-lambda~5~-stibanyl]phenyl}prop-2-enoic acid (3 entities in total)
Functional Keywords	leucine zipper, b-zip transcription factor, vitellogenin gene-binding protein (vbp), inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	9335.30
Authors	Stagno, J.R.,Ji, X. (deposition date: 2014-07-25, release date: 2014-08-06, Last modification date: 2023-08-30)
Primary citation	Zhao, J.,Stagno, J.R.,Varticovski, L.,Nimako, E.,Rishi, V.,McKinnon, K.,Akee, R.,Shoemaker, R.H.,Ji, X.,Vinson, C. P6981, an arylstibonic acid, is a novel low nanomolar inhibitor of cAMP response element-binding protein binding to DNA. Mol.Pharmacol., 82:814-823, 2012 Cited by PubMed: 22851716 DOI: 10.1124/mol.112.080820 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.301 Å)

Structure validation