1A3S
| HUMAN UBC9 | Descriptor: | UBC9 | Authors: | Naismith, J.H, Giraud, M. | Deposit date: | 1998-01-23 | Release date: | 1998-05-27 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of ubiquitin-conjugating enzyme 9 displays significant differences with other ubiquitin-conjugating enzymes which may reflect its specificity for sumo rather than ubiquitin. Acta Crystallogr.,Sect.D, 54, 1998
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7QUR
| SARS-CoV-2 Spike with ethylbenzamide-tri-iodo Siallyllactose, C3 symmetry | Descriptor: | 2,3,5-tris(iodanyl)benzamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Naismith, J.H, Yang, Y, Liu, J.W. | Deposit date: | 2022-01-18 | Release date: | 2022-06-01 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (2.27 Å) | Cite: | Pathogen-sugar interactions revealed by universal saturation transfer analysis. Science, 377, 2022
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7QUS
| SARS-CoV-2 Spike, C3 symmetry | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | Authors: | Naismith, J.H, Yang, Y, Liu, J.W. | Deposit date: | 2022-01-18 | Release date: | 2022-06-08 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (2.39 Å) | Cite: | Pathogen-sugar interactions revealed by universal saturation transfer analysis. Science, 377, 2022
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7OAN
| Nanobody C5 bound to Spike | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Naismith, J.H, Weckener, M. | Deposit date: | 2021-04-19 | Release date: | 2021-08-11 | Last modified: | 2021-10-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19. Nat Commun, 12, 2021
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7OAO
| Nanobody C5 bound to RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, C5 nanobody, ... | Authors: | Naismith, J.H, Mikolajek, H. | Deposit date: | 2021-04-19 | Release date: | 2021-08-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19. Nat Commun, 12, 2021
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7OAY
| Nanobody F2 bound to RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, F2 nanobody, Spike protein S1 | Authors: | Naismith, J.H, Mikolajek, H. | Deposit date: | 2021-04-20 | Release date: | 2021-08-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19. Nat Commun, 12, 2021
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7OAU
| Nanobody C5 bound to Kent variant RBD (N501Y) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C5, GLYCEROL, ... | Authors: | Naismith, J.H, Mikolajek, H. | Deposit date: | 2021-04-20 | Release date: | 2021-08-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19. Nat Commun, 12, 2021
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7OAQ
| Nanobody H3 AND C1 bound to RBD with Kent mutation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CITRIC ACID, ... | Authors: | Naismith, J.H, Mikolajek, H. | Deposit date: | 2021-04-20 | Release date: | 2021-08-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19. Nat Commun, 12, 2021
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7OAP
| Nanobody H3 AND C1 bound to RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C1 nanobody, CHLORIDE ION, ... | Authors: | Naismith, J.H, Mikolajek, H. | Deposit date: | 2021-04-19 | Release date: | 2021-08-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19. Nat Commun, 12, 2021
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5AJI
| MscS D67R1 high resolution | Descriptor: | DECANE, HEXANE, N-OCTANE, ... | Authors: | Naismith, J.H, Pliotas, C. | Deposit date: | 2015-02-24 | Release date: | 2015-07-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | The Role of Lipids in Mechanosensation. Nat.Struct.Mol.Biol., 22, 2015
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5H8C
| Truncated XPD | Descriptor: | IRON/SULFUR CLUSTER, XPD/Rad3 related DNA helicase | Authors: | Naismith, J.H, Constantinescu, D. | Deposit date: | 2015-12-23 | Release date: | 2016-01-13 | Last modified: | 2016-04-20 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Mechanism of DNA loading by the DNA repair helicase XPD. Nucleic Acids Res., 44, 2016
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5H8W
| XPD mechanism | Descriptor: | ATP-dependent DNA helicase Ta0057, DNA (5'-D(P*TP*AP*CP*GP*A)-3'), IRON/SULFUR CLUSTER, ... | Authors: | Naismith, J.H, Constantinescu, D. | Deposit date: | 2015-12-24 | Release date: | 2016-01-13 | Last modified: | 2016-04-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mechanism of DNA loading by the DNA repair helicase XPD. Nucleic Acids Res., 44, 2016
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5CNA
| REFINED STRUCTURE OF CONCANAVALIN A COMPLEXED WITH ALPHA-METHYL-D-MANNOPYRANOSIDE AT 2.0 ANGSTROMS RESOLUTION AND COMPARISON WITH THE SACCHARIDE-FREE STRUCTURE | Descriptor: | CALCIUM ION, CHLORIDE ION, CONCANAVALIN A, ... | Authors: | Naismith, J.H, Emmerich, C, Habash, J, Harrop, S.J, Helliwell, J.R, Hunter, W.N, Raftery, J, Kalb(Gilboa), A.J, Yariv, J. | Deposit date: | 1994-02-11 | Release date: | 1994-05-31 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Refined structure of concanavalin A complexed with methyl alpha-D-mannopyranoside at 2.0 A resolution and comparison with the saccharide-free structure. Acta Crystallogr.,Sect.D, 50, 1994
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1CVN
| CONCANAVALIN A COMPLEXED TO TRIMANNOSIDE | Descriptor: | CALCIUM ION, CONCANAVALIN A, MANGANESE (II) ION, ... | Authors: | Naismith, J.H. | Deposit date: | 1995-08-09 | Release date: | 1996-10-14 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis of trimannoside recognition by concanavalin A. J.Biol.Chem., 271, 1996
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1EXT
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1TEI
| STRUCTURE OF CONCANAVALIN A COMPLEXED TO BETA-D-GLCNAC (1,2)ALPHA-D-MAN-(1,6)[BETA-D-GLCNAC(1,2)ALPHA-D-MAN (1,6)]ALPHA-D-MAN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose, CALCIUM ION, CONCANAVALIN A, ... | Authors: | Naismith, J.H, Moothoo, D.N. | Deposit date: | 1997-05-28 | Release date: | 1997-08-20 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Concanavalin A distorts the beta-GlcNAc-(1-->2)-Man linkage of beta-GlcNAc-(1-->2)-alpha-Man-(1-->3)-[beta-GlcNAc-(1-->2)-alpha-Man- (1-->6)]-Man upon binding. Glycobiology, 8, 1998
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7NII
| Wzc-K540M MgADP C1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Putative transmembrane protein Wzc | Authors: | Naismith, J.H, Liu, J.W, Yang, Y. | Deposit date: | 2021-02-12 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | The molecular basis of regulation of bacterial capsule assembly by Wzc. Nat Commun, 12, 2021
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7NIH
| Wzc-K540M MgADP C8 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Putative transmembrane protein Wzc | Authors: | Naismith, J.H, Liu, J.W, Yang, Y. | Deposit date: | 2021-02-12 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | The molecular basis of regulation of bacterial capsule assembly by Wzc. Nat Commun, 12, 2021
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7NIB
| Wzc-K540M-4YE C1 | Descriptor: | Tyrosine-protein kinase | Authors: | Naismith, J.H, Liu, J.W, Yang, Y. | Deposit date: | 2021-02-11 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | The molecular basis of regulation of bacterial capsule assembly by Wzc. Nat Commun, 12, 2021
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7NI2
| Wzc-K540M-4YE C8 | Descriptor: | Tyrosine-protein kinase | Authors: | Naismith, J.H, Liu, J.W, Yang, Y. | Deposit date: | 2021-02-11 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | The molecular basis of regulation of bacterial capsule assembly by Wzc. Nat Commun, 12, 2021
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7NHS
| Wzc K540M C8 | Descriptor: | Putative transmembrane protein Wzc | Authors: | Naismith, J.H, Liu, J.W, Yang, Y. | Deposit date: | 2021-02-11 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | The molecular basis of regulation of bacterial capsule assembly by Wzc. Nat Commun, 12, 2021
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6ZH9
| Ternary complex CR3022 H11-H4 and RBD (SARS-CoV-2) | Descriptor: | CR3022 Light chain, CR3022 heavy, Nanobody H11-H4, ... | Authors: | Naismith, J.H, Mikolajek, H, Le Bas, A. | Deposit date: | 2020-06-21 | Release date: | 2020-09-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.31 Å) | Cite: | Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2. Nat.Struct.Mol.Biol., 27, 2020
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7AN4
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1CON
| THE REFINED STRUCTURE OF CADMIUM SUBSTITUTED CONCANAVALIN A AT 2.0 ANGSTROMS RESOLUTION | Descriptor: | CADMIUM ION, CALCIUM ION, CONCANAVALIN A | Authors: | Naismith, J.H, Habash, J, Harrop, S.J, Helliwell, J.R, Hunter, W.N, Kalb(Gilboa), A.J, Yariv, J, Wan, T.C.M, Weisgerber, S. | Deposit date: | 1993-03-16 | Release date: | 1994-01-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Refined structure of cadmium-substituted concanavalin A at 2.0 A resolution. Acta Crystallogr.,Sect.D, 49, 1993
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1NCF
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