7OAU

Nanobody C5 bound to Kent variant RBD (N501Y)

This is a non-PDB format compatible entry.

Summary for 7OAU

• Entry DOI: 10.2210/pdb7oau/pdb
• Descriptor: Spike protein S1, C5, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: rbd, nanobody, high affinity, antiviral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 4
• Total formula weight: 75880.86

Authors

Naismith, J.H.,Mikolajek, H. (deposition date: 2021-04-20, release date: 2021-08-11, Last modification date: 2024-01-31)

• Primary citation: Huo, J.,Mikolajek, H.,Le Bas, A.,Clark, J.J.,Sharma, P.,Kipar, A.,Dormon, J.,Norman, C.,Weckener, M.,Clare, D.K.,Harrison, P.J.,Tree, J.A.,Buttigieg, K.R.,Salguero, F.J.,Watson, R.,Knott, D.,Carnell, O.,Ngabo, D.,Elmore, M.J.,Fotheringham, S.,Harding, A.,Moynie, L.,Ward, P.N.,Dumoux, M.,Prince, T.,Hall, Y.,Hiscox, J.A.,Owen, A.,James, W.,Carroll, M.W.,Stewart, J.P.,Naismith, J.H.,Owens, R.J.; A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19.; Nat Commun, 12:5469-5469, 2021; PubMed: 34552091; DOI: 10.1038/s41467-021-25480-z

Experimental method

X-RAY DIFFRACTION (1.65 Å)