7OAN
Nanobody C5 bound to Spike
Summary for 7OAN
Entry DOI | 10.2210/pdb7oan/pdb |
EMDB information | 12777 |
Descriptor | Spike glycoprotein, immunoglobulin mu heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | spike, nanobody, high affinity, antiviral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) More |
Total number of polymer chains | 6 |
Total formula weight | 475685.79 |
Authors | Naismith, J.H.,Weckener, M. (deposition date: 2021-04-19, release date: 2021-08-11, Last modification date: 2021-10-06) |
Primary citation | Huo, J.,Mikolajek, H.,Le Bas, A.,Clark, J.J.,Sharma, P.,Kipar, A.,Dormon, J.,Norman, C.,Weckener, M.,Clare, D.K.,Harrison, P.J.,Tree, J.A.,Buttigieg, K.R.,Salguero, F.J.,Watson, R.,Knott, D.,Carnell, O.,Ngabo, D.,Elmore, M.J.,Fotheringham, S.,Harding, A.,Moynie, L.,Ward, P.N.,Dumoux, M.,Prince, T.,Hall, Y.,Hiscox, J.A.,Owen, A.,James, W.,Carroll, M.W.,Stewart, J.P.,Naismith, J.H.,Owens, R.J. A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19. Nat Commun, 12:5469-5469, 2021 Cited by PubMed: 34552091DOI: 10.1038/s41467-021-25480-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
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