2LGX
| NMR structure for Kindle-2 N-terminus | Descriptor: | Fermitin family homolog 2 | Authors: | Perera, H.D, Ma, Y, Yang, J, Hirbawi, J, Plow, E.F, Qin, J. | Deposit date: | 2011-08-03 | Release date: | 2011-11-30 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Membrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin Activation. Structure, 19, 2011
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1M8O
| Platelet integrin alfaIIb-beta3 cytoplasmic domain | Descriptor: | platelet integrin alfaIIb subunit: cytoplasmic domain, platelet integrin beta3 subunit: cytoplasmic domain | Authors: | Vinogradova, O, Velyvis, A, Velyviene, A, Hu, B, Haas, T, Plow, E.F, Qin, J. | Deposit date: | 2002-07-25 | Release date: | 2002-09-18 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A Structural mechanism of integrin alfaiib beta3
"Inside-out" Activation as regulated by its cytoplasmic face. Cell(Cambridge,Mass.), 110, 2002
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2KNC
| Platelet integrin ALFAIIB-BETA3 transmembrane-cytoplasmic heterocomplex | Descriptor: | Integrin alpha-IIb, Integrin beta-3 | Authors: | Yang, J, Ma, Y, Page, R.C, Misra, S, Plow, E.F, Qin, J. | Deposit date: | 2009-08-20 | Release date: | 2009-09-29 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Structure of an integrin alphaIIb beta3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation. Proc.Natl.Acad.Sci.USA, 106, 2009
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6MIB
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7LT9
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7LT8
| Crystal structure of Ras suppressor-1 | Descriptor: | Ras suppressor protein 1 | Authors: | Fukuda, K, Qin, J. | Deposit date: | 2021-02-19 | Release date: | 2021-04-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.76000249 Å) | Cite: | Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly. J.Biol.Chem., 296, 2021
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1U5S
| NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain | Descriptor: | Cytoplasmic protein NCK2, PINCH protein, ZINC ION | Authors: | Vaynberg, J, Fukuda, T, Vinogradova, O, Velyvis, A, Ng, L, Wu, C, Qin, J. | Deposit date: | 2004-07-28 | Release date: | 2005-04-05 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility. Mol.Cell, 17, 2005
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3Q4C
| Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292 | Descriptor: | Serine/threonine-protein kinase B-raf, [(1,2,3,4,5,6-eta)-(1S,2R,3R,4R,5S,6S)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5H-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~N~1~,N~12~)ruthenium(1+) | Authors: | Xie, P, Streu, C, Qin, J, Pregman, H, Pagano, N, Meggers, E, Marmorstein, R. | Deposit date: | 2010-12-23 | Release date: | 2011-03-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase. Biochemistry, 48, 2009
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1B4Q
| Solution structure of human thioltransferase complex with glutathione | Descriptor: | GLUTATHIONE, PROTEIN (HUMAN THIOLTRANSFERASE) | Authors: | Yang, Y, Jao, S.C, Nanduri, S, Starke, D.W, Mieyal, J.J, Qin, J. | Deposit date: | 1998-12-25 | Release date: | 1999-12-23 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Reactivity of the human thioltransferase (glutaredoxin) C7S, C25S, C78S, C82S mutant and NMR solution structure of its glutathionyl mixed disulfide intermediate reflect catalytic specificity. Biochemistry, 37, 1998
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2K2R
| The NMR structure of alpha-parvin CH2/paxillin LD1 complex | Descriptor: | Alpha-parvin, Paxillin | Authors: | Wang, X, Fukuda, K, Byeon, I, Velyvis, A, Wu, C, Gronenborn, A, Qin, J. | Deposit date: | 2008-04-10 | Release date: | 2008-05-27 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The Structure of {alpha}-Parvin CH2-Paxillin LD1 Complex Reveals a Novel Modular Recognition for Focal Adhesion Assembly. J.Biol.Chem., 283, 2008
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2K9U
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7F58
| Cryo-EM structure of THIQ-MC4R-Gs_Nb35 complex | Descriptor: | (3R)-N-[(2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxidanylidene-propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. | Deposit date: | 2021-06-21 | Release date: | 2021-11-03 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
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7F55
| Cryo-EM structure of bremelanotide-MC4R-Gs_Nb35 complex | Descriptor: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. | Deposit date: | 2021-06-21 | Release date: | 2021-11-03 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
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7F54
| Cryo-EM structure of afamelanotide-MC4R-Gs_Nb35 complex | Descriptor: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. | Deposit date: | 2021-06-21 | Release date: | 2021-11-03 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
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7F53
| Cryo-EM structure of a-MSH-MC4R-Gs_Nb35 complex | Descriptor: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. | Deposit date: | 2021-06-21 | Release date: | 2021-11-03 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
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7D72
| Cryo-EM structures of human GMPPA/GMPPB complex bound to GDP-Mannose | Descriptor: | GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, MAGNESIUM ION, Mannose-1-phosphate guanyltransferase alpha, ... | Authors: | Zheng, L, Liu, Z, Wang, Y, Yang, F, Wang, J, Qing, J, Cai, X, Mo, X, Gao, N, Jia, D. | Deposit date: | 2020-10-02 | Release date: | 2021-05-05 | Last modified: | 2021-06-02 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis. Nat.Struct.Mol.Biol., 28, 2021
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7D73
| Cryo-EM structure of GMPPA/GMPPB complex bound to GTP (State I) | Descriptor: | GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, GUANOSINE-5'-TRIPHOSPHATE, Mannose-1-phosphate guanyltransferase alpha, ... | Authors: | Zheng, L, Liu, Z, Wang, Y, Yang, F, Wang, J, Qing, J, Cai, X, Mo, X, Gao, N, Jia, D. | Deposit date: | 2020-10-02 | Release date: | 2021-05-05 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis. Nat.Struct.Mol.Biol., 28, 2021
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7D74
| Cryo-EM structure of GMPPA/GMPPB complex bound to GTP (state II) | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Mannose-1-phosphate guanyltransferase alpha, Mannose-1-phosphate guanyltransferase beta | Authors: | Zheng, L, Liu, Z, Wang, Y, Yang, F, Wang, J, Qing, J, cai, X, Mo, X, Gao, N, Jia, D. | Deposit date: | 2020-10-02 | Release date: | 2021-05-19 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis. Nat.Struct.Mol.Biol., 28, 2021
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2G35
| NMR structure of talin-PTB in complex with PIPKI | Descriptor: | Talin-1, peptide | Authors: | Kong, X, Wang, X, Misra, S, Qin, J. | Deposit date: | 2006-02-17 | Release date: | 2006-05-02 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Structural Basis for the Phosphorylation-regulated Focal Adhesion Targeting of Type Igamma Phosphatidylinositol Phosphate Kinase (PIPKIgamma) by Talin. J.Mol.Biol., 359, 2006
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8ID6
| Cryo-EM structure of the oleic acid bound GPR120-Gi complex | Descriptor: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID4
| Cryo-EM structure of the linoleic acid bound GPR120-Gi complex | Descriptor: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID9
| Cryo-EM structure of the eicosapentaenoic acid bound GPR120-Gi complex | Descriptor: | 5,8,11,14,17-EICOSAPENTAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID3
| Cryo-EM structure of the 9-hydroxystearic acid bound GPR120-Gi complex | Descriptor: | 9-Hydroxyoctadecanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID8
| Cryo-EM structure of the TUG891 bound GPR120-Gi complex | Descriptor: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8IKJ
| Cryo-EM structure of the inactive CD97 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Adhesion G protein-coupled receptor E5,Soluble cytochrome b562,Adhesion G protein-coupled receptor E5 subunit beta | Authors: | Mao, C, Zhao, R, Dong, Y, Gao, M, Chen, L, Zhang, C, Xiao, P, Guo, J, Qin, J, Shen, D, Ji, S, Zang, S, Zhang, H, Wang, W, Shen, Q, Sun, P, Zhang, Y. | Deposit date: | 2023-02-28 | Release date: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Conformational transitions and activation of the adhesion receptor CD97. Mol.Cell, 84, 2024
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