7D72

Cryo-EM structures of human GMPPA/GMPPB complex bound to GDP-Mannose

Summary for 7D72

• Entry DOI: 10.2210/pdb7d72/pdb
• EMDB information: 30599
• Descriptor: Mannose-1-phosphate guanyltransferase beta, Mannose-1-phosphate guanyltransferase alpha, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, ... (5 entities in total)
• Functional Keywords: gmppa, gmppb, gdp-mannose homeostasis, cell cycle, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 511731.38

Authors

Zheng, L.,Liu, Z.,Wang, Y.,Yang, F.,Wang, J.,Qing, J.,Cai, X.,Mo, X.,Gao, N.,Jia, D. (deposition date: 2020-10-02, release date: 2021-05-05, Last modification date: 2021-06-02)

• Primary citation: Zheng, L.,Liu, Z.,Wang, Y.,Yang, F.,Wang, J.,Huang, W.,Qin, J.,Tian, M.,Cai, X.,Liu, X.,Mo, X.,Gao, N.,Jia, D.; Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis.; Nat.Struct.Mol.Biol., 28:1-12, 2021; PubMed: 33986552; DOI: 10.1038/s41594-021-00591-9

Experimental method

ELECTRON MICROSCOPY (3.4 Å)