7D73

Cryo-EM structure of GMPPA/GMPPB complex bound to GTP (State I)

Summary for 7D73

Entry DOI	10.2210/pdb7d73/pdb
EMDB information	30600
Descriptor	Mannose-1-phosphate guanyltransferase alpha, Mannose-1-phosphate guanyltransferase beta, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, ... (4 entities in total)
Functional Keywords	gmppa, gmppb, gdp-mannose homeostasis, cell cycle, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	510836.85
Authors	Zheng, L.,Liu, Z.,Wang, Y.,Yang, F.,Wang, J.,Qing, J.,Cai, X.,Mo, X.,Gao, N.,Jia, D. (deposition date: 2020-10-02, release date: 2021-05-05, Last modification date: 2021-12-01)
Primary citation	Zheng, L.,Liu, Z.,Wang, Y.,Yang, F.,Wang, J.,Huang, W.,Qin, J.,Tian, M.,Cai, X.,Liu, X.,Mo, X.,Gao, N.,Jia, D. Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis. Nat.Struct.Mol.Biol., 28:1-12, 2021 Cited by PubMed: 33986552 DOI: 10.1038/s41594-021-00591-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation