8FLQ
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![BU of 8flq by Molmil](/molmil-images/mine/8flq) | Human PTH1R in complex with PTH(1-34) and Gs | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. | Deposit date: | 2022-12-22 | Release date: | 2023-04-26 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
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8FLS
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![BU of 8fls by Molmil](/molmil-images/mine/8fls) | Human PTH1R in complex with Abaloparatide and Gs | Descriptor: | Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. | Deposit date: | 2022-12-22 | Release date: | 2023-04-26 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
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3ML9
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![BU of 3ml9 by Molmil](/molmil-images/mine/3ml9) | |
4JOL
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![BU of 4jol by Molmil](/molmil-images/mine/4jol) | |
6ASG
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![BU of 6asg by Molmil](/molmil-images/mine/6asg) | Crystal structure of Thermus thermophilus RNA polymerase core enzyme | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Liu, Y, Lin, W, Ying, R, Ebright, R.H. | Deposit date: | 2017-08-24 | Release date: | 2018-04-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Mol. Cell, 70, 2018
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8GKA
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![BU of 8gka by Molmil](/molmil-images/mine/8gka) | Human TRPV3 tetramer structure, closed conformation | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | Authors: | Lansky, S, Betancourt, J.M, Scheuring, S. | Deposit date: | 2023-03-17 | Release date: | 2023-09-06 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | A pentameric TRPV3 channel with a dilated pore. Nature, 621, 2023
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8GKG
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![BU of 8gkg by Molmil](/molmil-images/mine/8gkg) | |
4FBG
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![BU of 4fbg by Molmil](/molmil-images/mine/4fbg) | Crystal structure of Treponema denticola trans-2-enoyl-CoA reductase in complex with NAD | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative reductase TDE_0597 | Authors: | Hu, K, Zhao, M, Zhang, T, Yang, S, Ding, J. | Deposit date: | 2012-05-23 | Release date: | 2012-11-28 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism Biochem.J., 449, 2013
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7M7D
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![BU of 7m7d by Molmil](/molmil-images/mine/7m7d) | Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with IACS-8968 | Descriptor: | (5S)-6,6-dimethyl-8-[(4S)-7-(trifluoromethyl)imidazo[1,5-a]pyridin-5-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dione, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Leonard, P.G, Cross, J.B. | Deposit date: | 2021-03-27 | Release date: | 2021-09-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme. J.Med.Chem., 64, 2021
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7M63
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![BU of 7m63 by Molmil](/molmil-images/mine/7m63) | Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with IACS-70099 | Descriptor: | (2R)-N-(4-chlorophenyl)-2-[(1R,3S,5S,6r)-3-(5,6-difluoro-1H-benzimidazol-1-yl)bicyclo[3.1.0]hexan-6-yl]propanamide, Indoleamine 2,3-dioxygenase 1 | Authors: | Leonard, P.G, Cross, J.B. | Deposit date: | 2021-03-25 | Release date: | 2021-09-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme. J.Med.Chem., 64, 2021
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5Y1U
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![BU of 5y1u by Molmil](/molmil-images/mine/5y1u) | Crystal structure of RBBP4 bound to AEBP2 RRK motif | Descriptor: | Histone-binding protein RBBP4, SULFATE ION, Zinc finger protein AEBP2 | Authors: | Sun, A, Li, F, Wu, J, Shi, Y. | Deposit date: | 2017-07-21 | Release date: | 2018-04-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.141 Å) | Cite: | Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4 Protein Cell, 2017
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3ML8
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![BU of 3ml8 by Molmil](/molmil-images/mine/3ml8) | |
4EUE
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![BU of 4eue by Molmil](/molmil-images/mine/4eue) | Crystal structure of Clostridium acetobutulicum trans-2-enoyl-CoA reductase in complex with NADH | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Putative reductase CA_C0462, SODIUM ION | Authors: | Hu, K, Zhao, M, Zhang, T, Yang, S, Ding, J. | Deposit date: | 2012-04-25 | Release date: | 2012-11-28 | Last modified: | 2013-07-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism Biochem.J., 449, 2013
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3HEA
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![BU of 3hea by Molmil](/molmil-images/mine/3hea) | The L29P/L124I mutation of Pseudomonas fluorescens esterase | Descriptor: | Arylesterase, ETHYL ACETATE, GLYCEROL, ... | Authors: | Kazlauskas, R.J, Schrag, J.D, Cheeseman, J.D, Morley, K.L. | Deposit date: | 2009-05-08 | Release date: | 2010-03-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase. Biochemistry, 49, 2010
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3HI4
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![BU of 3hi4 by Molmil](/molmil-images/mine/3hi4) | |
4EUF
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![BU of 4euf by Molmil](/molmil-images/mine/4euf) | Crystal structure of Clostridium acetobutulicum trans-2-enoyl-CoA reductase in complex with NAD | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative reductase CA_C0462, SODIUM ION | Authors: | Hu, K, Zhao, M, Zhang, T, Yang, S, Ding, J. | Deposit date: | 2012-04-25 | Release date: | 2012-11-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism Biochem.J., 449, 2013
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8IUM
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![BU of 8ium by Molmil](/molmil-images/mine/8ium) | Cryo-EM structure of the tafluprost acid-bound human PTGFR-Gq complex | Descriptor: | (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E})-3,3-bis(fluoranyl)-4-phenoxy-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, G subunit alpha (q), ... | Authors: | Wu, C, Xu, Y, Xu, H.E. | Deposit date: | 2023-03-24 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Ligand-induced activation and G protein coupling of prostaglandin F 2 alpha receptor. Nat Commun, 14, 2023
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8IUK
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![BU of 8iuk by Molmil](/molmil-images/mine/8iuk) | Cryo-EM structure of the PGF2-alpha-bound human PTGFR-Gq complex | Descriptor: | (Z)-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(E,3S)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, G subunit alpha (q), ... | Authors: | Wu, C, Xu, Y, Xu, H.E. | Deposit date: | 2023-03-24 | Release date: | 2023-07-12 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | Ligand-induced activation and G protein coupling of prostaglandin F 2 alpha receptor. Nat Commun, 14, 2023
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8IUL
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![BU of 8iul by Molmil](/molmil-images/mine/8iul) | Cryo-EM structure of the latanoprost-bound human PTGFR-Gq complex | Descriptor: | Antibody fragment scFv16, G subunit alpha (q), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Wu, C, Xu, Y, Xu, H.E. | Deposit date: | 2023-03-24 | Release date: | 2023-07-12 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | Ligand-induced activation and G protein coupling of prostaglandin F 2 alpha receptor. Nat Commun, 14, 2023
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8JPC
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![BU of 8jpc by Molmil](/molmil-images/mine/8jpc) | cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2 | Descriptor: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | Deposit date: | 2023-06-11 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8JPF
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![BU of 8jpf by Molmil](/molmil-images/mine/8jpf) | Focused refiment structure of NTSR1 in NTSR1-GRK2-Galpha(q) complexes | Descriptor: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, NTS, Neurotensin receptor type 1 | Authors: | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | Deposit date: | 2023-06-11 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8JPB
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![BU of 8jpb by Molmil](/molmil-images/mine/8jpb) | cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1 | Descriptor: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | Deposit date: | 2023-06-11 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8JPE
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![BU of 8jpe by Molmil](/molmil-images/mine/8jpe) | Focused refinement structure of Galpha(q) in NTSR1-GRK2-Galpha(q) complexes | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | Authors: | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | Deposit date: | 2023-06-11 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8JPD
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![BU of 8jpd by Molmil](/molmil-images/mine/8jpd) | Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes | Descriptor: | Beta-adrenergic receptor kinase 1, STAUROSPORINE | Authors: | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | Deposit date: | 2023-06-11 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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6AKJ
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![BU of 6akj by Molmil](/molmil-images/mine/6akj) | The crystal structure of EMC complex | Descriptor: | Enhancer of rudimentary homolog,YTH domain-containing protein mmi1 fusion protein, SULFATE ION | Authors: | Li, F. | Deposit date: | 2018-09-01 | Release date: | 2019-02-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing. Nat Commun, 10, 2019
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