4JOL

Complex structure of AML1-ETO NHR2 domain with HEB fragment

Summary for 4JOL

Entry DOI	10.2210/pdb4jol/pdb
Descriptor	Protein CBFA2T1, Transcription factor 12 (2 entities in total)
Functional Keywords	leukemia; aml1-eto; heb; nhr2 domain, dna binding protein
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: Q06455 Q99081
Total number of polymer chains	8
Total formula weight	42632.38
Authors	Wang, Z.,Patel, D.J. (deposition date: 2013-03-18, release date: 2013-06-26, Last modification date: 2023-09-20)
Primary citation	Sun, X.J.,Wang, Z.,Wang, L.,Jiang, Y.,Kost, N.,Soong, T.D.,Chen, W.Y.,Tang, Z.,Nakadai, T.,Elemento, O.,Fischle, W.,Melnick, A.,Patel, D.J.,Nimer, S.D.,Roeder, R.G. A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Nature, 500:93-97, 2013 Cited by PubMed: 23812588 DOI: 10.1038/nature12287 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.906 Å)

Structure validation