4JOL

Complex structure of AML1-ETO NHR2 domain with HEB fragment

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Protein CBFA2T1	polymer	64	8036.0	4	UniProt (Q06455) Pfam (PF08788) In PDB	Homo sapiens (human)	Cyclin-D-related protein, Eight twenty one protein, Protein ETO, Protein MTG8, Zinc finger MYND domain-containing protein 2
2	E, F, G, H	Transcription factor 12	polymer	25	2622.1	4	UniProt (Q99081) In PDB	Homo sapiens (human)	TCF-12, Class B basic helix-loop-helix protein 20, bHLHb20, DNA-binding protein HTF4, E-box-binding protein, Transcription factor HTF-4

Sequence modifications

A, B, C, D: 486 - 548 (UniProt: Q06455)

PDB	External Database	Details
Ser 485	-	expression tag

E, F, G, H: 177 - 200 (UniProt: Q99081)

PDB	External Database	Details
Ser 176	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	42632.4
All*	Total formula weight	42632.4

*Water molecules are not included.