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3NYO
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BU of 3nyo by Molmil
Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with AMP
Descriptor: (R,R)-2,3-BUTANEDIOL, ADENOSINE MONOPHOSPHATE, G protein-coupled receptor kinase 6, ...
Authors:Tesmer, J.J.G, Singh, P.
Deposit date:2010-07-15
Release date:2010-09-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Molecular basis for activation of G protein-coupled receptor kinases.
Embo J., 29, 2010
1AZT
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BU of 1azt by Molmil
GS-ALPHA COMPLEXED WITH GTP-GAMMA-S
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GS-ALPHA, MAGNESIUM ION, ...
Authors:Tesmer, J.J.G, Sprang, S.R.
Deposit date:1997-11-20
Release date:1998-02-25
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the adenylyl cyclase activator Gsalpha
Science, 278, 1997
2BCJ
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BU of 2bcj by Molmil
Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits
Descriptor: G-protein-coupled receptor kinase 2, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Tesmer, J.J.G.
Deposit date:2005-10-19
Release date:2005-12-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.061 Å)
Cite:Snapshot of Activated G Proteins at the Membrane: The Gq-GRK2-G Complex
Science, 310, 2005
4WBO
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BU of 4wbo by Molmil
Bovine G Protein Coupled Receptor Kinase 1 in Complex with Amlexanox
Descriptor: 2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid, CHLORIDE ION, Rhodopsin kinase
Authors:Homan, K.T, Tesmer, J.J.G.
Deposit date:2014-09-03
Release date:2014-11-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Identification and characterization of amlexanox as a g protein-coupled receptor kinase 5 inhibitor.
Molecules, 19, 2014
5UKL
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BU of 5ukl by Molmil
Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd)
Descriptor: 2-{5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluorophenyl}-N-[2-(1H-pyrazol-4-yl)ethyl]acetamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cato, M.C, Homan, K.T, Tesmer, J.J.G.
Deposit date:2017-01-23
Release date:2017-04-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
J. Med. Chem., 60, 2017
2I1J
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BU of 2i1j by Molmil
Moesin from Spodoptera frugiperda at 2.1 angstroms resolution
Descriptor: CHLORIDE ION, GLYCEROL, Moesin, ...
Authors:Li, Q, Nance, M.R, Tesmer, J.J.G.
Deposit date:2006-08-14
Release date:2006-12-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central alpha-Helical Domain.
J.Mol.Biol., 365, 2007
2I1K
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BU of 2i1k by Molmil
Moesin from Spodoptera frugiperda reveals the coiled-coil domain at 3.0 angstrom resolution
Descriptor: CHLORIDE ION, GLYCEROL, Moesin, ...
Authors:Nance, M.R, Tesmer, J.J.G.
Deposit date:2006-08-14
Release date:2006-12-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central alpha-Helical Domain.
J.Mol.Biol., 365, 2007
5D3W
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BU of 5d3w by Molmil
Crystal Structure of the P-Rex1 PH domain with Sulfate Bound
Descriptor: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, SULFATE ION
Authors:Cash, J.N, Tesmer, J.J.G.
Deposit date:2015-08-06
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.852 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5D3X
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BU of 5d3x by Molmil
Crystal Structure of the P-Rex1 PH domain with Inositol-(1,3,4,5)-Tetrakisphosphate Bound
Descriptor: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Authors:Cash, J.N, Tesmer, J.J.G.
Deposit date:2015-08-06
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5D27
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BU of 5d27 by Molmil
Crystal Structure of the P-Rex1 PH domain
Descriptor: NICKEL (II) ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Authors:Cash, J.N, Tesmer, J.J.G.
Deposit date:2015-08-05
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5D3Y
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BU of 5d3y by Molmil
Crystal Structure of the P-Rex1 PH domain with Inositol-(1,3,4,5)-Tetrakisphosphate Bound
Descriptor: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Authors:Cash, J.N, Tesmer, J.J.G.
Deposit date:2015-08-06
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
8ABP
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BU of 8abp by Molmil
SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES OF AN ARABINOSE-BINDING PROTEIN MUTANT (MET108LEU) WHICH EXHIBITS ENHANCED AFFINITY AND ALTERED SPECIFICITY
Descriptor: L-ARABINOSE-BINDING PROTEIN, alpha-D-galactopyranose, beta-D-galactopyranose
Authors:Vermersch, P.S, Tesmer, J.J.G, Quiocho, F.A.
Deposit date:1991-04-25
Release date:1991-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity.
Biochemistry, 30, 1991
9ABP
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BU of 9abp by Molmil
A PRO TO GLY MUTATION IN THE HINGE OF THE ARABINOSE-BINDING PROTEIN ENHANCES BINDING AND ALTERS SPECIFICITY: SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES
Descriptor: L-ARABINOSE-BINDING PROTEIN, alpha-D-galactopyranose, beta-D-galactopyranose
Authors:Vermersch, P.S, Tesmer, J.J.G, Quiocho, F.A.
Deposit date:1991-11-15
Release date:1992-01-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.
J.Biol.Chem., 265, 1990
1X86
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BU of 1x86 by Molmil
Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF in complex with RhoA
Descriptor: PHOSPHATE ION, Rho guanine nucleotide exchange factor 12, Transforming protein RhoA
Authors:Kristelly, R, Gao, G, Tesmer, J.J.
Deposit date:2004-08-17
Release date:2004-09-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.
J.Biol.Chem., 279, 2004
1TXD
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BU of 1txd by Molmil
Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF
Descriptor: Rho guanine nucleotide exchange factor 12
Authors:Kristelly, R, Gao, G, Tesmer, J.J.
Deposit date:2004-07-03
Release date:2004-09-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.
J.Biol.Chem., 279, 2004
6MVD
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BU of 6mvd by Molmil
Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in complex with isopropyl dodec-11-enylfluorophosphonate (IDFP) and a small molecule activator
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-{4-[(4R)-4-hydroxy-6-oxo-4-(trifluoromethyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridin-3-yl]piperidin-1-yl}-4-(trifluoromethyl)pyridine-3-carbonitrile, NICKEL (II) ION, ...
Authors:Manthei, K.A, Chang, L, Tesmer, J.J.G.
Deposit date:2018-10-25
Release date:2018-12-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.
Elife, 7, 2018
4L9I
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BU of 4l9i by Molmil
Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Paroxetine, ...
Authors:Homan, K.T, Tesmer, J.J.G.
Deposit date:2013-06-18
Release date:2014-01-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.
Mol.Pharmacol., 85, 2014
5D3V
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BU of 5d3v by Molmil
Crystal Structure of the P-Rex1 PH domain with Citrate Bound
Descriptor: CITRATE ANION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Authors:Cash, J.N, Tesmer, J.J.G.
Deposit date:2015-08-06
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.852 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
2RGN
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BU of 2rgn by Molmil
Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ...
Authors:Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G.
Deposit date:2007-10-04
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Science, 318, 2007
7ABP
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BU of 7abp by Molmil
SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES OF AN ARABINOSE-BINDING PROTEIN MUTANT (MET108LEU) WHICH EXHIBITS ENHANCED AFFINITY AND ALTERED SPECIFICITY
Descriptor: L-ARABINOSE-BINDING PROTEIN, alpha-D-fucopyranose, beta-D-fucopyranose
Authors:Vermersch, P.S, Tesmer, J.J.G, Quiocho, F.A.
Deposit date:1991-04-25
Release date:1991-10-15
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity.
Biochemistry, 30, 1991
5FI0
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BU of 5fi0 by Molmil
Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1
Descriptor: PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1
Authors:Cash, J.N, Tesmer, J.J.G.
Deposit date:2015-12-22
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.282 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
6ABP
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BU of 6abp by Molmil
SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES OF AN ARABINOSE-BINDING PROTEIN MUTANT (MET108LEU) WHICH EXHIBITS ENHANCED AFFINITY AND ALTERED SPECIFICITY
Descriptor: L-ARABINOSE-BINDING PROTEIN, alpha-L-arabinopyranose, beta-L-arabinopyranose
Authors:Vermersch, P.S, Tesmer, J.J.G, Quiocho, F.A.
Deposit date:1991-04-25
Release date:1991-10-31
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity.
Biochemistry, 30, 1991
5FI1
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BU of 5fi1 by Molmil
Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42
Descriptor: Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Authors:Cash, J.N, Tesmer, J.J.G.
Deposit date:2015-12-22
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.203 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5DO9
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BU of 5do9 by Molmil
Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ...
Authors:Taylor, V.G, Tesmer, J.J.G.
Deposit date:2015-09-10
Release date:2016-01-20
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the Regulator of G Protein Signaling 8 (RGS8)-G alpha q Complex: MOLECULAR BASIS FOR G alpha SELECTIVITY.
J.Biol.Chem., 291, 2016
4GNK
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BU of 4gnk by Molmil
Crystal structure of Galphaq in complex with full-length human PLCbeta3
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Lyon, A.M, Tesmer, J.J.G.
Deposit date:2012-08-17
Release date:2013-02-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Full-length G alpha (q)-phospholipase C-beta 3 structure reveals interfaces of the C-terminal coiled-coil domain.
Nat.Struct.Mol.Biol., 20, 2013

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