5D27

Crystal Structure of the P-Rex1 PH domain

Summary for 5D27

Entry DOI	10.2210/pdb5d27/pdb
Descriptor	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, NICKEL (II) ION (3 entities in total)
Functional Keywords	pleckstrin homology domain, beta sandwich, phosphatidylinositol-binding, lipid binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	19345.65
Authors	Cash, J.N.,Tesmer, J.J.G. (deposition date: 2015-08-05, release date: 2016-04-20, Last modification date: 2023-09-27)
Primary citation	Cash, J.N.,Davis, E.M.,Tesmer, J.J. Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24:730-740, 2016 Cited by PubMed: 27150042 DOI: 10.1016/j.str.2016.02.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation