1TXD
Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF
Summary for 1TXD
| Entry DOI | 10.2210/pdb1txd/pdb |
| Descriptor | Rho guanine nucleotide exchange factor 12 (2 entities in total) |
| Functional Keywords | helical bundle (dh), beta sandwich (ph), signaling protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm (Probable): Q9NZN5 |
| Total number of polymer chains | 1 |
| Total formula weight | 44694.29 |
| Authors | Kristelly, R.,Gao, G.,Tesmer, J.J. (deposition date: 2004-07-03, release date: 2004-09-21, Last modification date: 2024-02-14) |
| Primary citation | Kristelly, R.,Gao, G.,Tesmer, J.J. Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. J.Biol.Chem., 279:47352-47362, 2004 Cited by PubMed: 15331592DOI: 10.1074/jbc.M406056200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.13 Å) |
Structure validation
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