1TXD
Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Rho guanine nucleotide exchange factor 12 | polymer | 385 | 44694.3 | 1 | UniProt (Q9NZN5) Pfam (PF00621) Pfam (PF17838) In PDB | Homo sapiens (human) | Leukemia-associated RhoGEF |
| 2 | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A: 764 - 1138 (UniProt: Q9NZN5)
| PDB | External Database | Details |
|---|---|---|
| Gly 764 | Thr 764 | cloning artifact |
| Ser 765 | Asp 765 | cloning artifact |
| Phe 973 | Tyr 973 | engineered mutation |
| Val 1139 | - | cloning artifact |
| Asp 1140 | - | cloning artifact |
| Gly 1141 | - | cloning artifact |
| Gly 1142 | - | cloning artifact |
| His 1143 | - | expression tag |
| His 1144 | - | expression tag |
| His 1145 | - | expression tag |
| His 1146 | - | expression tag |
| His 1147 | - | expression tag |
| His 1148 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44694.3 | |
| All* | Total formula weight | 44694.3 |
