1X86
Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF in complex with RhoA
Summary for 1X86
Entry DOI | 10.2210/pdb1x86/pdb |
Related | 1TXD |
Descriptor | Rho guanine nucleotide exchange factor 12, Transforming protein RhoA, PHOSPHATE ION (3 entities in total) |
Functional Keywords | helical bundle (dh), beta sandwich (ph), alpha/beta (rhoa), signaling protein-membrane protein complex, signaling protein/membrane protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm (Probable): Q9NZN5 Cell membrane; Lipid-anchor; Cytoplasmic side: P61586 |
Total number of polymer chains | 8 |
Total formula weight | 267687.05 |
Authors | Kristelly, R.,Gao, G.,Tesmer, J.J. (deposition date: 2004-08-17, release date: 2004-09-21, Last modification date: 2024-02-14) |
Primary citation | Kristelly, R.,Gao, G.,Tesmer, J.J. Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. J.Biol.Chem., 279:47352-47362, 2004 Cited by PubMed: 15331592DOI: 10.1074/jbc.M406056200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.22 Å) |
Structure validation
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