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1X86

Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF in complex with RhoA

Functional Information from GO Data
ChainGOidnamespacecontents
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0035556biological_processintracellular signal transduction
B0000902biological_processcell morphogenesis
B0001764biological_processneuron migration
B0001822biological_processkidney development
B0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
B0002363biological_processalpha-beta T cell lineage commitment
B0003100biological_processregulation of systemic arterial blood pressure by endothelin
B0003189biological_processaortic valve formation
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0005938cellular_componentcell cortex
B0006357biological_processregulation of transcription by RNA polymerase II
B0007010biological_processcytoskeleton organization
B0007155biological_processcell adhesion
B0007160biological_processcell-matrix adhesion
B0007264biological_processsmall GTPase-mediated signal transduction
B0007266biological_processRho protein signal transduction
B0007519biological_processskeletal muscle tissue development
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010812biological_processnegative regulation of cell-substrate adhesion
B0010975biological_processregulation of neuron projection development
B0016477biological_processcell migration
B0016787molecular_functionhydrolase activity
B0017022molecular_functionmyosin binding
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0021795biological_processcerebral cortex cell migration
B0021861biological_processforebrain radial glial cell differentiation
B0030027cellular_componentlamellipodium
B0030036biological_processactin cytoskeleton organization
B0030054cellular_componentcell junction
B0030154biological_processcell differentiation
B0030334biological_processregulation of cell migration
B0030425cellular_componentdendrite
B0030496cellular_componentmidbody
B0030521biological_processandrogen receptor signaling pathway
B0030667cellular_componentsecretory granule membrane
B0031122biological_processcytoplasmic microtubule organization
B0031982cellular_componentvesicle
B0032154cellular_componentcleavage furrow
B0032467biological_processpositive regulation of cytokinesis
B0032587cellular_componentruffle membrane
B0032956biological_processregulation of actin cytoskeleton organization
B0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
B0033688biological_processregulation of osteoblast proliferation
B0034329biological_processcell junction assembly
B0034446biological_processsubstrate adhesion-dependent cell spreading
B0035385biological_processRoundabout signaling pathway
B0036089biological_processcleavage furrow formation
B0038027biological_processapolipoprotein A-I-mediated signaling pathway
B0042476biological_processodontogenesis
B0042995cellular_componentcell projection
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043149biological_processstress fiber assembly
B0043197cellular_componentdendritic spine
B0043296cellular_componentapical junction complex
B0043297biological_processapical junction assembly
B0043366biological_processbeta selection
B0043542biological_processendothelial cell migration
B0043931biological_processossification involved in bone maturation
B0044319biological_processwound healing, spreading of cells
B0045198biological_processestablishment of epithelial cell apical/basal polarity
B0045666biological_processpositive regulation of neuron differentiation
B0045792biological_processnegative regulation of cell size
B0046638biological_processpositive regulation of alpha-beta T cell differentiation
B0050919biological_processnegative chemotaxis
B0051301biological_processcell division
B0051496biological_processpositive regulation of stress fiber assembly
B0051893biological_processregulation of focal adhesion assembly
B0060071biological_processWnt signaling pathway, planar cell polarity pathway
B0060193biological_processpositive regulation of lipase activity
B0061430biological_processbone trabecula morphogenesis
B0070062cellular_componentextracellular exosome
B0070507biological_processregulation of microtubule cytoskeleton organization
B0071222biological_processcellular response to lipopolysaccharide
B0071345biological_processcellular response to cytokine stimulus
B0071526biological_processsemaphorin-plexin signaling pathway
B0071803biological_processpositive regulation of podosome assembly
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0071944cellular_componentcell periphery
B0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
B0090307biological_processmitotic spindle assembly
B0090324biological_processnegative regulation of oxidative phosphorylation
B0097049biological_processmotor neuron apoptotic process
B0097498biological_processendothelial tube lumen extension
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099159biological_processregulation of modification of postsynaptic structure
B0101003cellular_componentficolin-1-rich granule membrane
B1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
B1902766biological_processskeletal muscle satellite cell migration
B1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
B1903673biological_processmitotic cleavage furrow formation
B1904695biological_processpositive regulation of vascular associated smooth muscle contraction
B1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
B1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
B1990869biological_processcellular response to chemokine
B2000177biological_processregulation of neural precursor cell proliferation
B2000406biological_processpositive regulation of T cell migration
B2000672biological_processnegative regulation of motor neuron apoptotic process
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0035556biological_processintracellular signal transduction
D0000902biological_processcell morphogenesis
D0001764biological_processneuron migration
D0001822biological_processkidney development
D0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
D0002363biological_processalpha-beta T cell lineage commitment
D0003100biological_processregulation of systemic arterial blood pressure by endothelin
D0003189biological_processaortic valve formation
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005789cellular_componentendoplasmic reticulum membrane
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0005938cellular_componentcell cortex
D0006357biological_processregulation of transcription by RNA polymerase II
D0007010biological_processcytoskeleton organization
D0007155biological_processcell adhesion
D0007160biological_processcell-matrix adhesion
D0007264biological_processsmall GTPase-mediated signal transduction
D0007266biological_processRho protein signal transduction
D0007519biological_processskeletal muscle tissue development
D0009898cellular_componentcytoplasmic side of plasma membrane
D0010812biological_processnegative regulation of cell-substrate adhesion
D0010975biological_processregulation of neuron projection development
D0016477biological_processcell migration
D0016787molecular_functionhydrolase activity
D0017022molecular_functionmyosin binding
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0021795biological_processcerebral cortex cell migration
D0021861biological_processforebrain radial glial cell differentiation
D0030027cellular_componentlamellipodium
D0030036biological_processactin cytoskeleton organization
D0030054cellular_componentcell junction
D0030154biological_processcell differentiation
D0030334biological_processregulation of cell migration
D0030425cellular_componentdendrite
D0030496cellular_componentmidbody
D0030521biological_processandrogen receptor signaling pathway
D0030667cellular_componentsecretory granule membrane
D0031122biological_processcytoplasmic microtubule organization
D0031982cellular_componentvesicle
D0032154cellular_componentcleavage furrow
D0032467biological_processpositive regulation of cytokinesis
D0032587cellular_componentruffle membrane
D0032956biological_processregulation of actin cytoskeleton organization
D0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
D0033688biological_processregulation of osteoblast proliferation
D0034329biological_processcell junction assembly
D0034446biological_processsubstrate adhesion-dependent cell spreading
D0035385biological_processRoundabout signaling pathway
D0036089biological_processcleavage furrow formation
D0038027biological_processapolipoprotein A-I-mediated signaling pathway
D0042476biological_processodontogenesis
D0042995cellular_componentcell projection
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043149biological_processstress fiber assembly
D0043197cellular_componentdendritic spine
D0043296cellular_componentapical junction complex
D0043297biological_processapical junction assembly
D0043366biological_processbeta selection
D0043542biological_processendothelial cell migration
D0043931biological_processossification involved in bone maturation
D0044319biological_processwound healing, spreading of cells
D0045198biological_processestablishment of epithelial cell apical/basal polarity
D0045666biological_processpositive regulation of neuron differentiation
D0045792biological_processnegative regulation of cell size
D0046638biological_processpositive regulation of alpha-beta T cell differentiation
D0050919biological_processnegative chemotaxis
D0051301biological_processcell division
D0051496biological_processpositive regulation of stress fiber assembly
D0051893biological_processregulation of focal adhesion assembly
D0060071biological_processWnt signaling pathway, planar cell polarity pathway
D0060193biological_processpositive regulation of lipase activity
D0061430biological_processbone trabecula morphogenesis
D0070062cellular_componentextracellular exosome
D0070507biological_processregulation of microtubule cytoskeleton organization
D0071222biological_processcellular response to lipopolysaccharide
D0071345biological_processcellular response to cytokine stimulus
D0071526biological_processsemaphorin-plexin signaling pathway
D0071803biological_processpositive regulation of podosome assembly
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0071944cellular_componentcell periphery
D0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
D0090307biological_processmitotic spindle assembly
D0090324biological_processnegative regulation of oxidative phosphorylation
D0097049biological_processmotor neuron apoptotic process
D0097498biological_processendothelial tube lumen extension
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099159biological_processregulation of modification of postsynaptic structure
D0101003cellular_componentficolin-1-rich granule membrane
D1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
D1902766biological_processskeletal muscle satellite cell migration
D1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
D1903673biological_processmitotic cleavage furrow formation
D1904695biological_processpositive regulation of vascular associated smooth muscle contraction
D1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
D1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
D1990869biological_processcellular response to chemokine
D2000177biological_processregulation of neural precursor cell proliferation
D2000406biological_processpositive regulation of T cell migration
D2000672biological_processnegative regulation of motor neuron apoptotic process
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0035556biological_processintracellular signal transduction
F0000902biological_processcell morphogenesis
F0001764biological_processneuron migration
F0001822biological_processkidney development
F0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
F0002363biological_processalpha-beta T cell lineage commitment
F0003100biological_processregulation of systemic arterial blood pressure by endothelin
F0003189biological_processaortic valve formation
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005768cellular_componentendosome
F0005789cellular_componentendoplasmic reticulum membrane
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0005938cellular_componentcell cortex
F0006357biological_processregulation of transcription by RNA polymerase II
F0007010biological_processcytoskeleton organization
F0007155biological_processcell adhesion
F0007160biological_processcell-matrix adhesion
F0007264biological_processsmall GTPase-mediated signal transduction
F0007266biological_processRho protein signal transduction
F0007519biological_processskeletal muscle tissue development
F0009898cellular_componentcytoplasmic side of plasma membrane
F0010812biological_processnegative regulation of cell-substrate adhesion
F0010975biological_processregulation of neuron projection development
F0016477biological_processcell migration
F0016787molecular_functionhydrolase activity
F0017022molecular_functionmyosin binding
F0019901molecular_functionprotein kinase binding
F0021762biological_processsubstantia nigra development
F0021795biological_processcerebral cortex cell migration
F0021861biological_processforebrain radial glial cell differentiation
F0030027cellular_componentlamellipodium
F0030036biological_processactin cytoskeleton organization
F0030054cellular_componentcell junction
F0030154biological_processcell differentiation
F0030334biological_processregulation of cell migration
F0030425cellular_componentdendrite
F0030496cellular_componentmidbody
F0030521biological_processandrogen receptor signaling pathway
F0030667cellular_componentsecretory granule membrane
F0031122biological_processcytoplasmic microtubule organization
F0031982cellular_componentvesicle
F0032154cellular_componentcleavage furrow
F0032467biological_processpositive regulation of cytokinesis
F0032587cellular_componentruffle membrane
F0032956biological_processregulation of actin cytoskeleton organization
F0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
F0033688biological_processregulation of osteoblast proliferation
F0034329biological_processcell junction assembly
F0034446biological_processsubstrate adhesion-dependent cell spreading
F0035385biological_processRoundabout signaling pathway
F0036089biological_processcleavage furrow formation
F0038027biological_processapolipoprotein A-I-mediated signaling pathway
F0042476biological_processodontogenesis
F0042995cellular_componentcell projection
F0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
F0043149biological_processstress fiber assembly
F0043197cellular_componentdendritic spine
F0043296cellular_componentapical junction complex
F0043297biological_processapical junction assembly
F0043366biological_processbeta selection
F0043542biological_processendothelial cell migration
F0043931biological_processossification involved in bone maturation
F0044319biological_processwound healing, spreading of cells
F0045198biological_processestablishment of epithelial cell apical/basal polarity
F0045666biological_processpositive regulation of neuron differentiation
F0045792biological_processnegative regulation of cell size
F0046638biological_processpositive regulation of alpha-beta T cell differentiation
F0050919biological_processnegative chemotaxis
F0051301biological_processcell division
F0051496biological_processpositive regulation of stress fiber assembly
F0051893biological_processregulation of focal adhesion assembly
F0060071biological_processWnt signaling pathway, planar cell polarity pathway
F0060193biological_processpositive regulation of lipase activity
F0061430biological_processbone trabecula morphogenesis
F0070062cellular_componentextracellular exosome
F0070507biological_processregulation of microtubule cytoskeleton organization
F0071222biological_processcellular response to lipopolysaccharide
F0071345biological_processcellular response to cytokine stimulus
F0071526biological_processsemaphorin-plexin signaling pathway
F0071803biological_processpositive regulation of podosome assembly
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0071944cellular_componentcell periphery
F0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
F0090307biological_processmitotic spindle assembly
F0090324biological_processnegative regulation of oxidative phosphorylation
F0097049biological_processmotor neuron apoptotic process
F0097498biological_processendothelial tube lumen extension
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F0099159biological_processregulation of modification of postsynaptic structure
F0101003cellular_componentficolin-1-rich granule membrane
F1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
F1902766biological_processskeletal muscle satellite cell migration
F1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
F1903673biological_processmitotic cleavage furrow formation
F1904695biological_processpositive regulation of vascular associated smooth muscle contraction
F1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
F1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
F1990869biological_processcellular response to chemokine
F2000177biological_processregulation of neural precursor cell proliferation
F2000406biological_processpositive regulation of T cell migration
F2000672biological_processnegative regulation of motor neuron apoptotic process
G0005085molecular_functionguanyl-nucleotide exchange factor activity
G0035556biological_processintracellular signal transduction
H0000902biological_processcell morphogenesis
H0001764biological_processneuron migration
H0001822biological_processkidney development
H0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
H0002363biological_processalpha-beta T cell lineage commitment
H0003100biological_processregulation of systemic arterial blood pressure by endothelin
H0003189biological_processaortic valve formation
H0003924molecular_functionGTPase activity
H0003925molecular_functionG protein activity
H0005515molecular_functionprotein binding
H0005525molecular_functionGTP binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005768cellular_componentendosome
H0005789cellular_componentendoplasmic reticulum membrane
H0005829cellular_componentcytosol
H0005856cellular_componentcytoskeleton
H0005886cellular_componentplasma membrane
H0005925cellular_componentfocal adhesion
H0005938cellular_componentcell cortex
H0006357biological_processregulation of transcription by RNA polymerase II
H0007010biological_processcytoskeleton organization
H0007155biological_processcell adhesion
H0007160biological_processcell-matrix adhesion
H0007264biological_processsmall GTPase-mediated signal transduction
H0007266biological_processRho protein signal transduction
H0007519biological_processskeletal muscle tissue development
H0009898cellular_componentcytoplasmic side of plasma membrane
H0010812biological_processnegative regulation of cell-substrate adhesion
H0010975biological_processregulation of neuron projection development
H0016477biological_processcell migration
H0016787molecular_functionhydrolase activity
H0017022molecular_functionmyosin binding
H0019901molecular_functionprotein kinase binding
H0021762biological_processsubstantia nigra development
H0021795biological_processcerebral cortex cell migration
H0021861biological_processforebrain radial glial cell differentiation
H0030027cellular_componentlamellipodium
H0030036biological_processactin cytoskeleton organization
H0030054cellular_componentcell junction
H0030154biological_processcell differentiation
H0030334biological_processregulation of cell migration
H0030425cellular_componentdendrite
H0030496cellular_componentmidbody
H0030521biological_processandrogen receptor signaling pathway
H0030667cellular_componentsecretory granule membrane
H0031122biological_processcytoplasmic microtubule organization
H0031982cellular_componentvesicle
H0032154cellular_componentcleavage furrow
H0032467biological_processpositive regulation of cytokinesis
H0032587cellular_componentruffle membrane
H0032956biological_processregulation of actin cytoskeleton organization
H0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
H0033688biological_processregulation of osteoblast proliferation
H0034329biological_processcell junction assembly
H0034446biological_processsubstrate adhesion-dependent cell spreading
H0035385biological_processRoundabout signaling pathway
H0036089biological_processcleavage furrow formation
H0038027biological_processapolipoprotein A-I-mediated signaling pathway
H0042476biological_processodontogenesis
H0042995cellular_componentcell projection
H0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
H0043149biological_processstress fiber assembly
H0043197cellular_componentdendritic spine
H0043296cellular_componentapical junction complex
H0043297biological_processapical junction assembly
H0043366biological_processbeta selection
H0043542biological_processendothelial cell migration
H0043931biological_processossification involved in bone maturation
H0044319biological_processwound healing, spreading of cells
H0045198biological_processestablishment of epithelial cell apical/basal polarity
H0045666biological_processpositive regulation of neuron differentiation
H0045792biological_processnegative regulation of cell size
H0046638biological_processpositive regulation of alpha-beta T cell differentiation
H0050919biological_processnegative chemotaxis
H0051301biological_processcell division
H0051496biological_processpositive regulation of stress fiber assembly
H0051893biological_processregulation of focal adhesion assembly
H0060071biological_processWnt signaling pathway, planar cell polarity pathway
H0060193biological_processpositive regulation of lipase activity
H0061430biological_processbone trabecula morphogenesis
H0070062cellular_componentextracellular exosome
H0070507biological_processregulation of microtubule cytoskeleton organization
H0071222biological_processcellular response to lipopolysaccharide
H0071345biological_processcellular response to cytokine stimulus
H0071526biological_processsemaphorin-plexin signaling pathway
H0071803biological_processpositive regulation of podosome assembly
H0071902biological_processpositive regulation of protein serine/threonine kinase activity
H0071944cellular_componentcell periphery
H0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
H0090307biological_processmitotic spindle assembly
H0090324biological_processnegative regulation of oxidative phosphorylation
H0097049biological_processmotor neuron apoptotic process
H0097498biological_processendothelial tube lumen extension
H0098794cellular_componentpostsynapse
H0098978cellular_componentglutamatergic synapse
H0099159biological_processregulation of modification of postsynaptic structure
H0101003cellular_componentficolin-1-rich granule membrane
H1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
H1902766biological_processskeletal muscle satellite cell migration
H1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
H1903673biological_processmitotic cleavage furrow formation
H1904695biological_processpositive regulation of vascular associated smooth muscle contraction
H1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
H1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
H1990869biological_processcellular response to chemokine
H2000177biological_processregulation of neural precursor cell proliferation
H2000406biological_processpositive regulation of T cell migration
H2000672biological_processnegative regulation of motor neuron apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 B 401
ChainResidue
BGLY17
BLYS18
BTHR19
BCYS20

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 D 402
ChainResidue
DGLY17
DLYS18
DTHR19
DCYS20

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PO4 F 403
ChainResidue
FALA15
FGLY17
FLYS18
FTHR19
FGLY14

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 H 404
ChainResidue
HGLY17
HCYS20
HVAL35
HLYS118

Functional Information from PROSITE/UniProt
site_idPS00741
Number of Residues26
DetailsDH_1 Dbl homology (DH) domain signature. LkdIIptQMqrLtKypLlLdNIakyT
ChainResidueDetails
ALEU926-THR951

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804
ChainResidueDetails
BGLY12
BASN117
DGLY12
DASN117
FGLY12
FASN117
HGLY12
HASN117

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P62820
ChainResidueDetails
BPHE30
HPHE30
HASP59
HSER160
BASP59
BSER160
DPHE30
DASP59
DSER160
FPHE30
FASP59
FSER160

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: (Microbial infection) Cleavage; by yopT => ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863
ChainResidueDetails
BGLY189
DGLY189
FGLY189
HGLY189

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
BTYR34
DTYR34
FTYR34
HTYR34

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
BTHR37
DTHR37
FTHR37
HTHR37

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: (Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305|PubMed:1328215
ChainResidueDetails
BASN41
DASN41
FASN41
HASN41

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0
ChainResidueDetails
BGLN63
DGLN63
FGLN63
HGLN63

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKG/PRKG1 => ECO:0000269|PubMed:11162591
ChainResidueDetails
BSER188
DSER188
FSER188
HSER188

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P61585
ChainResidueDetails
BCYS190
DCYS190
FCYS190
HCYS190

site_idSWS_FT_FI10
Number of Residues12
DetailsLIPID: (Microbial infection) N6-stearoyl lysine => ECO:0000269|PubMed:30061757
ChainResidueDetails
BLYS185
HLYS185
HLYS186
HLYS187
BLYS186
BLYS187
DLYS185
DLYS186
DLYS187
FLYS185
FLYS186
FLYS187

site_idSWS_FT_FI11
Number of Residues4
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P61585
ChainResidueDetails
BCYS190
DCYS190
FCYS190
HCYS190

site_idSWS_FT_FI12
Number of Residues4
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
BTYR34
DTYR34
FTYR34
HTYR34

site_idSWS_FT_FI13
Number of Residues4
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
BTHR37
DTHR37
FTHR37
HTHR37

site_idSWS_FT_FI14
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831
ChainResidueDetails
BLYS135
DLYS135
FLYS135
HLYS135

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BGLN63

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
DGLN63

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
FGLN63

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
HGLN63

224572

PDB entries from 2024-09-04

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