1X86
Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF in complex with RhoA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G | Rho guanine nucleotide exchange factor 12 | polymer | 385 | 44694.3 | 4 | UniProt (Q9NZN5) Pfam (PF00621) Pfam (PF17838) In PDB | Homo sapiens (human) | Leukemia-associated RhoGEF |
| 2 | B, D, F, H | Transforming protein RhoA | polymer | 196 | 22132.5 | 4 | UniProt (P61586) Pfam (PF00071) In PDB | Homo sapiens (human) | H12 |
| 3 | B, D, F, H | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) |
Sequence modifications
A, C, E, G: 764 - 1138 (UniProt: Q9NZN5)
B, D, F, H: 1 - 193 (UniProt: P61586)
| PDB | External Database | Details |
|---|---|---|
| Gly 764 | Thr 764 | cloning artifact |
| Ser 765 | Asp 765 | cloning artifact |
| Phe 973 | Tyr 973 | engineered mutation |
| Val 1139 | - | cloning artifact |
| Asp 1140 | - | cloning artifact |
| Gly 1141 | - | cloning artifact |
| Gly 1142 | - | cloning artifact |
| His 1143 | - | expression tag |
| His 1144 | - | expression tag |
| His 1145 | - | expression tag |
| His 1146 | - | expression tag |
| His 1147 | - | expression tag |
| His 1148 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | cloning artifact |
| Glu -1 | - | cloning artifact |
| Phe 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 267307.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 379.9 | |
| All* | Total formula weight | 267687.0 |
