4AFJ
5-aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors
Summary for 4AFJ
Entry DOI | 10.2210/pdb4afj/pdb |
Related | 1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2UW9 2X37 2X39 2XH5 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH |
Descriptor | GLYCOGEN SYNTHASE KINASE-3 BETA, PROTO-ONCOGENE FRAT1, SULFATE ION, ... (6 entities in total) |
Functional Keywords | transferase-peptide complex, kinase, transferase/peptide |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 4 |
Total formula weight | 92207.25 |
Authors | Gentile, G.,Merlo, G.,Pozzan, A.,Bernasconi, G.,Bax, B.,Bamborough, P.,Bridges, A.,Carter, P.,Neu, M.,Yao, G.,Brough, C.,Cutler, G.,Coffin, A.,Belyanskaya, S. (deposition date: 2012-01-19, release date: 2012-02-29, Last modification date: 2023-12-20) |
Primary citation | Gentile, G.,Merlo, G.,Pozzan, A.,Bernasconi, G.,Bax, B.,Bamborough, P.,Bridges, A.,Carter, P.,Neu, M.,Yao, G.,Brough, C.,Cutler, G.,Coffin, A.,Belyanskaya, S. 5-Aryl-4-Carboxamide-1,3-Oxazoles: Potent and Selective Gsk-3 Inhibitors. Bioorg.Med.Chem.Lett., 22:1989-, 2012 Cited by PubMed: 22310227DOI: 10.1016/J.BMCL.2012.01.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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