4AFJ

5-aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors

Summary for 4AFJ

Entry DOI	10.2210/pdb4afj/pdb
Related	1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2UW9 2X37 2X39 2XH5 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH
Descriptor	GLYCOGEN SYNTHASE KINASE-3 BETA, PROTO-ONCOGENE FRAT1, SULFATE ION, ... (6 entities in total)
Functional Keywords	transferase-peptide complex, kinase, transferase/peptide
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	4
Total formula weight	92207.25
Authors	Gentile, G.,Merlo, G.,Pozzan, A.,Bernasconi, G.,Bax, B.,Bamborough, P.,Bridges, A.,Carter, P.,Neu, M.,Yao, G.,Brough, C.,Cutler, G.,Coffin, A.,Belyanskaya, S. (deposition date: 2012-01-19, release date: 2012-02-29, Last modification date: 2024-10-16)
Primary citation	Gentile, G.,Merlo, G.,Pozzan, A.,Bernasconi, G.,Bax, B.,Bamborough, P.,Bridges, A.,Carter, P.,Neu, M.,Yao, G.,Brough, C.,Cutler, G.,Coffin, A.,Belyanskaya, S. 5-Aryl-4-Carboxamide-1,3-Oxazoles: Potent and Selective Gsk-3 Inhibitors. Bioorg.Med.Chem.Lett., 22:1989-, 2012 Cited by PubMed Abstract: 5-Aryl-4-carboxamide-1,3-oxazoles are a novel, potent and selective series of GSK-3 inhibitors. The optimization of the series to yield compounds with cell activity and brain permeability is described. PubMed: 22310227 DOI: 10.1016/J.BMCL.2012.01.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation