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4ACH

GSK3b in complex with inhibitor

Summary for 4ACH
Entry DOI10.2210/pdb4ach/pdb
Related1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2UW9 2X37 2X39 2XH5 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4AFJ
DescriptorGLYCOGEN SYNTHASE KINASE-3 BETA, 3-AMINO-N-(3-METHOXYPROPYL)-6-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}PYRAZINE-2-CARBOXAMIDE (3 entities in total)
Functional Keywordstransferase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm : P49841
Total number of polymer chains2
Total formula weight105046.81
Authors
Xue, Y.,Ormo, M. (deposition date: 2011-12-15, release date: 2012-05-16, Last modification date: 2018-02-14)
Primary citationBerg, S.,Bergh, M.,Hellberg, S.,Hogdin, K.,Lo-Alfredsson, Y.,Soderman, P.,von Berg, S.,Weigelt, T.,Ormo, M.,Xue, Y.,Tucker, J.,Neelissen, J.,Jerning, E.,Nilsson, Y.,Bhat, R.
Discovery of novel potent and highly selective glycogen synthase kinase-3 beta (GSK3 beta ) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines.
J. Med. Chem., 55:9107-9119, 2012
Cited by
PubMed: 22489897
DOI: 10.1021/jm201724m
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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