2JDO
STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE
Summary for 2JDO
Entry DOI | 10.2210/pdb2jdo/pdb |
Related | 1GNG 1GZK 1GZN 1GZO 1H8F 1I09 1J1B 1J1C 1MRV 1MRY 1O6K 1O6L 1O9U 1P6S 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDR 2JDS 2JDT 2JDV |
Descriptor | RAC-BETA SERINE/THREONINE-PROTEIN KINASE, GLYCOGEN SYNTHASE KINASE-3 BETA, ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE, ... (5 entities in total) |
Functional Keywords | wnt signaling pathway, serine/threonine-protein kinase, kinase, transferase, atp-binding, phosphorylation, nucleotide-binding, alternative splicing |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm: P49841 |
Total number of polymer chains | 2 |
Total formula weight | 41465.60 |
Authors | Davies, T.G.,Verdonk, M.L.,Graham, B.,Saalau-Bethell, S.,Hamlett, C.C.F.,Mchardy, T.,Collins, I.,Garrett, M.D.,Workman, P.,Woodhead, S.J.,Jhoti, H.,Barford, D. (deposition date: 2007-01-11, release date: 2007-02-13, Last modification date: 2011-07-13) |
Primary citation | Davies, T.G.,Verdonk, M.L.,Graham, B.,Saalau-Bethell, S.,Hamlett, C.C.F.,Mchardy, T.,Collins, I.,Garrett, M.D.,Workman, P.,Woodhead, S.J.,Jhoti, H.,Barford, D. A Structural Comparison of Inhibitor Binding to Pkb, Pka and Pka-Pkb Chimera J.Mol.Biol., 367:882-, 2007 Cited by PubMed: 17275837DOI: 10.1016/J.JMB.2007.01.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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