2JDR

STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-443654

Summary for 2JDR

• Entry DOI: 10.2210/pdb2jdr/pdb
• Related: 1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO
• Descriptor: RAC-BETA SERINE/THREONINE-PROTEIN KINASE, GLYCOGEN SYNTHASE KINASE-3 BETA, (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE, ... (4 entities in total)
• Functional Keywords: wnt signaling pathway, serine/threonine-protein kinase, kinase, transferase, atp-binding, phosphorylation, nucleotide-binding, alternative splicing
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm: P49841
• Total number of polymer chains: 2
• Total formula weight: 41381.08

Authors

Davies, T.G.,Verdonk, M.L.,Graham, B.,Saalau-Bethell, S.,Hamlett, C.C.F.,McHardy, T.,Collins, I.,Garrett, M.D.,Workman, P.,Woodhead, S.J.,Jhoti, H.,Barford, D. (deposition date: 2007-01-12, release date: 2007-02-13, Last modification date: 2011-07-13)

• Primary citation: Davies, T.G.,Verdonk, M.L.,Graham, B.,Saalau-Bethell, S.,Hamlett, C.C.F.,Mchardy, T.,Collins, I.,Garrett, M.D.,Workman, P.,Woodhead, S.J.,Jhoti, H.,Barford, D.; A Structural Comparison of Inhibitor Binding to Pkb, Pka and Pka-Pkb Chimera; J.Mol.Biol., 367:882-, 2007; PubMed: 17275837; DOI: 10.1016/J.JMB.2007.01.004

Experimental method

X-RAY DIFFRACTION (2.3 Å)