2JDR

STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-443654

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	RAC-BETA SERINE/THREONINE-PROTEIN KINASE	polymer	342	39860.4	1	UniProt (P31751) Pfam (PF00069) Pfam (PF00433) In PDB	HOMO SAPIENS (HUMAN)	RAC-PK-BETA, PROTEIN KINASE AKT-2, PROTEIN KINASE B, BETA, PKB BETA, PROTEIN KINASE B-BETA
2	C	GLYCOGEN SYNTHASE KINASE-3 BETA	polymer	10	1123.2	1	UniProt (P49841) In PDB	HOMO SAPIENS	GSK3-BETA PEPTIDE, GSK-3 BETA
3	A	(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE	non-polymer		397.5	1	Chemie (L20)
4		water	water		18.0	105	Chemie (HOH)

Sequence modifications

A: 141 - 145 (PDB: 2JDR)
A: 465 - 479 (PDB: 2JDR)
A: 146 - 464 (UniProt: P31751)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	40983.6
Non-Polymers*	Number of molecules	1
	Total formula weight	397.5
All*	Total formula weight	41381.1

*Water molecules are not included.