2JDT

Structure of PKA-PKB chimera complexed with ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE

Summary for 2JDT

• Entry DOI: 10.2210/pdb2jdt/pdb
• Related: 1CMK 1KMU 1KMW 1Q24 1Q61 1Q62 1Q8T 1Q8U 1Q8W 1SMH 1STC 1SVE 1SVG 1SVH 1SZM 1VEB 1XH4 1XH5 1XH6 1XH7 1XH8 1XH9 1XHA 1YDR 1YDS 1YDT 2C1A 2C1B 2F7E 2GFC 2GNF 2GNG 2GNH 2GNI 2GNJ 2GNL 2JDO 2JDR 2JDS 2JDV
• Descriptor: CAMP-DEPENDENT PROTEIN KINASE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE, ... (4 entities in total)
• Functional Keywords: camp, kinase, myristate, transferase, lipoprotein, serine/threonine-protein kinase, nucleotide-binding, protein kinase inhibitor, atp-binding, nuclear protein, phosphorylation
• Biological source: BOS TAURUS (BOVINE); More
• Cellular location: Cytoplasm: P00517
• Total number of polymer chains: 2
• Total formula weight: 43476.95

Authors

Davies, T.G.,Verdonk, M.L.,Graham, B.,Saalau-Bethell, S.,Hamlett, C.C.F.,McHardy, T.,Collins, I.,Garrett, M.D.,Workman, P.,Woodhead, S.J.,Jhoti, H.,Barford, D. (deposition date: 2007-01-12, release date: 2007-02-13, Last modification date: 2023-12-13)

• Primary citation: Davies, T.G.,Verdonk, M.L.,Graham, B.,Saalau-Bethell, S.,Hamlett, C.C.F.,Mchardy, T.,Collins, I.,Garrett, M.D.,Workman, P.,Woodhead, S.J.,Jhoti, H.,Barford, D.; A Structural Comparison of Inhibitor Binding to Pkb, Pka and Pka-Pkb Chimera; J.Mol.Biol., 367:882-, 2007; PubMed: 17275837; DOI: 10.1016/J.JMB.2007.01.004

Experimental method

X-RAY DIFFRACTION (2.15 Å)