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1XH8

Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

Summary for 1XH8
Entry DOI10.2210/pdb1xh8/pdb
Related1SVE 1SVG 1SVH 1VEB 1XH4 1XH5 1XH6 1XH7 1XH9 1XHA
DescriptorcAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, N-[4-({4-[5-(4,4-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, ... (4 entities in total)
Functional Keywordspka, kinase-inhibitor-complex, serine/threonine-protein kinase, balanol derivative, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceBos taurus (cattle)
More
Cellular locationCytoplasm: P00517
Total number of polymer chains2
Total formula weight43502.52
Authors
Breitenlechner, C.B.,Friebe, W.-G.,Brunet, E.,Werner, G.,Graul, K.,Thomas, U.,Kuenkele, K.-P.,Schaefer, W.,Gassel, M.,Bossemeyer, D.,Huber, R.,Engh, R.A.,Masjost, B. (deposition date: 2004-09-17, release date: 2005-09-17, Last modification date: 2011-07-13)
Primary citationBreitenlechner, C.B.,Friebe, W.-G.,Brunet, E.,Werner, G.,Graul, K.,Thomas, U.,Kuenkele, K.-P.,Schaefer, W.,Gassel, M.,Bossemeyer, D.,Huber, R.,Engh, R.A.,Masjost, B.
Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants
J.Med.Chem., 48:163-170, 2005
Cited by
PubMed: 15634010
DOI: 10.1021/jm049701n
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

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