1YDS

Structure of CAMP-dependent protein kinase, alpha-catalytic subunit in complex with H8 protein kinase inhibitor [N-(2-methylamino)ethyl]-5-isoquinolinesulfonamide

Summary for 1YDS

Entry DOI	10.2210/pdb1yds/pdb
Descriptor	C-AMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR PEPTIDE, N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE, ... (4 entities in total)
Functional Keywords	phosphotransferase, transferase, camp, phosphorylation, isoquinoline sulfonamide, serine/threonine-protein kinase, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Bos taurus (cattle)
Cellular location	Cytoplasm: P00517
Total number of polymer chains	2
Total formula weight	43173.10
Authors	Engh, R.A.,Girod, A.,Kinzel, V.,Huber, R.,Bossemeyer, D. (deposition date: 1996-07-24, release date: 1997-04-01, Last modification date: 2012-02-15)
Primary citation	Engh, R.A.,Girod, A.,Kinzel, V.,Huber, R.,Bossemeyer, D. Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J.Biol.Chem., 271:26157-26164, 1996 Cited by PubMed: 8824261 DOI: 10.1074/jbc.271.42.26157 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation