1YDS
Structure of CAMP-dependent protein kinase, alpha-catalytic subunit in complex with H8 protein kinase inhibitor [N-(2-methylamino)ethyl]-5-isoquinolinesulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | E | C-AMP-DEPENDENT PROTEIN KINASE | polymer | 350 | 40681.4 | 1 | UniProt (P00517) Pfam (PF00069) In PDB | Bos taurus (cattle) | CAPK, PKA C-ALPHA |
| 2 | I | PROTEIN KINASE INHIBITOR PEPTIDE | polymer | 20 | 2226.4 | 1 | UniProt (P04541) UniProt (by SIFTS) (P63249) In PDB | PKI, PKI-ALPHA | |
| 3 | E | N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE | non-polymer | 265.3 | 1 | Chemie (IQS) | |||
| 4 | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
E: 1 - 350 (UniProt: P00517)
| PDB | External Database | Details |
|---|---|---|
| Ala 124 | Pro 124 | conflict |
| Asp 286 | Asn 286 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42907.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 265.3 | |
| All* | Total formula weight | 43173.1 |
