2JDT

Structure of PKA-PKB chimera complexed with ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	CAMP-DEPENDENT PROTEIN KINASE	polymer	351	40830.6	1	UniProt (P00517) Pfam (PF00069) In PDB	BOS TAURUS (BOVINE)	PROTEIN KINASE A, PKA C-ALPHA
2	I	CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA	polymer	20	2226.4	1	UniProt (P61925) In PDB	HOMO SAPIENS	PKI-ALPHA, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR
3	A	ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE	non-polymer		419.9	1	Chemie (I5S)
4		water	water		18.0	294	Chemie (HOH)

Sequence modifications

A: 0 - 0 (PDB: 2JDT)
A: 1 - 350 (UniProt: P00517)

PDB	External Database	Details
Thr 104	Val 104	engineered mutation
Ala 123	Val 123	engineered mutation
Met 173	Leu 173	engineered mutation
Lys 181	Gln 181	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	43057.0
Non-Polymers*	Number of molecules	1
	Total formula weight	419.9
All*	Total formula weight	43477.0

*Water molecules are not included.