4AFJ
5-aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | GLYCOGEN SYNTHASE KINASE-3 BETA | polymer | 367 | 41613.6 | 2 | UniProt (P49841) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | GSK3-BETA, SERINE/THREONINE-PROTEIN KINASE GSK3B |
| 2 | C, D (X, Y) | PROTO-ONCOGENE FRAT1 | polymer | 30 | 3570.2 | 2 | UniProt (Q92837) | HOMO SAPIENS (HUMAN) | FREQUENTLY REARRANGED IN ADVANCED T-CELL LYMPHOMAS 1, FRAT-1 |
| 3 | E, F, G, L, M... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | H, I, J, O, P... (A, B) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 5 | K, S (A, B) | 5-(4-METHOXYPHENYL)-N-(PYRIDIN-4-YLMETHYL)-1,3-OXAZOLE-4-CARBOXAMIDE | non-polymer | 309.3 | 2 | Chemie (SJJ) | |||
| 6 | T, U, V, W (A, B, X, Y) | water | water | 18.0 | 346 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 90367.6 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1839.7 | |
| All* | Total formula weight | 92207.3 |
